Отправить статью по E-mail CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects
- Авторы: Ivanova S.A.1,2, Filipenko M.L.3, Vyalova N.M.1, Voronina E.N.3, Pozhidaev I.V.1,4, Osmanova D.Z.1,4, Ivanov M.V.5, Fedorenko O.Y.1,2, Semke A.V.1, Bokhan N.A.1,4
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Учреждения:
- Research Institute of Mental Health
- National Research Tomsk Polytechnical University
- Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
- National Research Tomsk State University
- St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
- Выпуск: Том 160, № 5 (2016)
- Страницы: 687-690
- Раздел: Genetics
- URL: https://journal-vniispk.ru/0007-4888/article/view/236892
- DOI: https://doi.org/10.1007/s10517-016-3250-4
- ID: 236892
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Аннотация
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
Об авторах
S. Ivanova
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Автор, ответственный за переписку.
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk; Tomsk
M. Filipenko
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Россия, Novosibirsk
N. Vyalova
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk
E. Voronina
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Россия, Novosibirsk
I. Pozhidaev
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk; Tomsk
D. Osmanova
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk; Tomsk
M. Ivanov
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
Email: svetlana@mail.tomsknet.ru
Россия, St. Petersburg
O. Fedorenko
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk; Tomsk
A. Semke
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk
N. Bokhan
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Россия, Tomsk; Tomsk
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