Отправить статью по E-mail Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity
- Авторы: Sakharov D.A.1,2, Rudakovskaya P.G.3, Maltseva D.V.1, Trushkin E.V.1, Tonevitskaya S.A.2
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Учреждения:
- BioClinicum Research and Development Center
- Moscow State University of Mechanical Engineering (MAMI)
- National University of Science and Technology (MISiS)
- Выпуск: Том 161, № 1 (2016)
- Страницы: 116-119
- Раздел: Biotechnologies
- URL: https://journal-vniispk.ru/0007-4888/article/view/237179
- DOI: https://doi.org/10.1007/s10517-016-3359-5
- ID: 237179
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Аннотация
The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
Об авторах
D. Sakharov
BioClinicum Research and Development Center; Moscow State University of Mechanical Engineering (MAMI)
Автор, ответственный за переписку.
Email: d.sakharov@bioclinicum.com
Россия, Moscow; Moscow
P. Rudakovskaya
National University of Science and Technology (MISiS)
Email: d.sakharov@bioclinicum.com
Россия, Moscow
D. Maltseva
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Россия, Moscow
E. Trushkin
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Россия, Moscow
S. Tonevitskaya
Moscow State University of Mechanical Engineering (MAMI)
Email: d.sakharov@bioclinicum.com
Россия, Moscow
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