Отправить статью по E-mail Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis
- Авторы: Kononova T.E.1, Urazova O.I.1, Novitskii V.V.1, Esimova I.E.1, Churina E.G.1,2
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Учреждения:
- Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
- Выпуск: Том 165, № 3 (2018)
- Страницы: 311-314
- Раздел: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/240257
- DOI: https://doi.org/10.1007/s10517-018-4157-z
- ID: 240257
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Аннотация
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
Об авторах
T. Kononova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: kononova.te@gmail.com
Россия, Tomsk
O. Urazova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Россия, Tomsk
V. Novitskii
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Россия, Tomsk
I. Esimova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Россия, Tomsk
E. Churina
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation; Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
Email: kononova.te@gmail.com
Россия, Tomsk; Tomsk
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