Отправить статью по E-mail Secretome of Cultured Human Endothelial Cells in Simulated Microgravity
- Авторы: Kashirina D.N.1, Kononikhin A.S.1, Larina I.M.1, Buravkova L.B.1
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Учреждения:
- State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
- Выпуск: Том 167, № 1 (2019)
- Страницы: 35-38
- Раздел: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/241422
- DOI: https://doi.org/10.1007/s10517-019-04454-8
- ID: 241422
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Аннотация
The secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and in modeled microgravity for 24 h was studied by chromatography-mass spectrometry. In the secretome of cells exposed to microgravity, we identified a group of microtubule proteins including many structural elements of microtubules and regulatory proteins interacting with Rho-GTPases. Hence, reorganization of actin cytoskeleton and microtubules induced by microgravity is under complex regulation mediated by Rho proteins.
Об авторах
D. Kashirina
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: daryakudryavtseva@mail.ru
Россия, Moscow
A. Kononikhin
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Россия, Moscow
I. Larina
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Россия, Moscow
L. Buravkova
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Россия, Moscow
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