Immune complexes that contain HIV antigens activate peripheral blood T cells
- Autores: Korolevskaya L.B.1,2, Shmagel K.V.1,2, Saidakova E.V.1,2, Shmagel N.G.2,3, Chereshnev V.A.2,4
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Ural Division
- Perm State National Research University
- Perm AIDS Center
- Institute of Immunology and Physiology, Ural Dividion
- Edição: Volume 469, Nº 1 (2016)
- Páginas: 196-198
- Seção: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153816
- DOI: https://doi.org/10.1134/S0012496616040062
- ID: 153816
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Resumo
Uninfected donor T cells were treated in vitro by model immune complexes that contained either HIV or hepatitis C virus (HCV) antigens. Unlike HCV antigen-containing complexes, the immune complexes that contained HIV antigens have been shown to activate peripheral blood T cells of uninfected donors under in vitro conditions. Both the antiviral antibodies and HIV antigen were involved in the activation process. The unique properties of the immune complexes formed by HIV antigens and antiviral antibodies are believed to result from the virus-specific antibody properties and molecular conformation of the antigen–antibody complex.
Sobre autores
L. Korolevskaya
Institute of Ecology and Genetics of Microorganisms, Ural Division; Perm State National Research University
Autor responsável pela correspondência
Email: bioqueen@mail.ru
Rússia, Perm; Perm
K. Shmagel
Institute of Ecology and Genetics of Microorganisms, Ural Division; Perm State National Research University
Email: bioqueen@mail.ru
Rússia, Perm; Perm
E. Saidakova
Institute of Ecology and Genetics of Microorganisms, Ural Division; Perm State National Research University
Email: bioqueen@mail.ru
Rússia, Perm; Perm
N. Shmagel
Perm State National Research University; Perm AIDS Center
Email: bioqueen@mail.ru
Rússia, Perm; Perm
V. Chereshnev
Perm State National Research University; Institute of Immunology and Physiology, Ural Dividion
Email: bioqueen@mail.ru
Rússia, Perm; Yekaterinburg
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