Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity


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Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7–Hsp70 complex, which is accompanied by a loss of both the Tag7–Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium.

作者简介

E. Romanova

Institute of Gene Biology

Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

E. Dukhanina

Institute of Gene Biology

Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

T. Sharapova

Institute of Gene Biology

Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

L. Sashchenko

Institute of Gene Biology

Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

N. Gnuchev

Institute of Gene Biology

Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

D. Yashin

Institute of Gene Biology

编辑信件的主要联系方式.
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow

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