Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity
- 作者: Romanova E.A.1, Dukhanina E.A.1, Sharapova T.N.1, Sashchenko L.P.1, Gnuchev N.V.1, Yashin D.V.1
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隶属关系:
- Institute of Gene Biology
- 期: 卷 472, 编号 1 (2017)
- 页面: 31-33
- 栏目: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153982
- DOI: https://doi.org/10.1134/S0012496617010094
- ID: 153982
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详细
Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7–Hsp70 complex, which is accompanied by a loss of both the Tag7–Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium.
作者简介
E. Romanova
Institute of Gene Biology
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
E. Dukhanina
Institute of Gene Biology
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
T. Sharapova
Institute of Gene Biology
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
L. Sashchenko
Institute of Gene Biology
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
N. Gnuchev
Institute of Gene Biology
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
D. Yashin
Institute of Gene Biology
编辑信件的主要联系方式.
Email: yashin_co@mail.ru
俄罗斯联邦, Moscow
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