Environmentally benign (Green) synthesis of Cobazole, an efficient erythropoiesis-stimulating agent

Abstract

A practicable and environmentally benign process for the synthesis of Cobazole, an erythropoiesisstimulating agent, has been developed. The process is based on the reaction of N-vinylimidazole with cobalt chloride in water and requires no toxic organic solvents, which ensures the preparation of high-purity product.