New Adamantane Derivatives with NO-Generating Fragment

I. V. Serkov; A. N. Proshin; A. K. Ustinov; B. V. Lednev; E. V. Fomina-Ageeva; A. M. Ashba; V. V. Bezuglov; S. O. Bachurin

doi:10.1134/S0012500818010044

New Adamantane Derivatives with NO-Generating Fragment

作者: Serkov I.V.¹, Proshin A.N.¹, Ustinov A.K.¹, Lednev B.V.¹, Fomina-Ageeva E.V.², Ashba A.M.², Bezuglov V.V.², Bachurin S.O.¹
隶属关系:
1. Institute of Physiologically Active Substances
2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
期: 卷 478, 编号 1 (2018)
页面: 9-11
栏目: Chemistry
URL: https://journal-vniispk.ru/0012-5008/article/view/154164
DOI: https://doi.org/10.1134/S0012500818010044
ID: 154164

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详细

An approach to the synthesis of adamantane derivatives with NO-generating fragment containing nitroxy group has been developed. 1-Aminoadamantane, memantine, and adamantanecarboxylic acid have been used as initial compounds. The prepared compounds have shown ability to generate nitric oxide in a system mimicking biological reactions of nitro group reduction.