Spectral–luminescent study of a hydrogel based on hyaluronic acid dialdehyde and chitosan succinate containing the Lucentis drug
- Авторлар: Ostakhov S.S.1, Kayumova R.R.1, Vildanova R.R.1, Sigaeva N.N.1, Khusnitdinov I.I.2, Kolesov S.V.1, Khursan S.L.1
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Мекемелер:
- Ufa Institute of Chemistry
- Ufa Eye Research Institute
- Шығарылым: Том 52, № 1 (2018)
- Беттер: 34-37
- Бөлім: Photonics
- URL: https://journal-vniispk.ru/0018-1439/article/view/157312
- DOI: https://doi.org/10.1134/S0018143918010083
- ID: 157312
Дәйексөз келтіру
Аннотация
A spectral-luminescent study of the hydrogel formed by the crosslinking of chitosan succinate and hyaluronic acid dialdehyde (HAD) macromolecules, which is a dosage form of the Lucentis drug (active ingredient, ranibizumab), has been conducted. The individual fluorescence (FL) spectra of Lucentis (λmax = 336 nm), HAD (λmax = 328 and 438 nm), and the hydrogel (λmax = 396 nm) have been obtained. An analysis of these spectra suggests the participation of carbonyl groups and proteins contained in HAD in its gelation with chitosan succinate. The diffusion of Lucentis from the hydrogel into a physiological solution was studied by a FL method to demonstrate the high prolonged-release properties of the new dosage form.
Негізгі сөздер
Авторлар туралы
S. Ostakhov
Ufa Institute of Chemistry
Хат алмасуға жауапты Автор.
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
R. Kayumova
Ufa Institute of Chemistry
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
R. Vildanova
Ufa Institute of Chemistry
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
N. Sigaeva
Ufa Institute of Chemistry
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
I. Khusnitdinov
Ufa Eye Research Institute
Email: ostahov@anrb.ru
Ресей, Ufa, 450008 Bashkortostan
S. Kolesov
Ufa Institute of Chemistry
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
S. Khursan
Ufa Institute of Chemistry
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan
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