Spectral–luminescent study of a hydrogel based on hyaluronic acid dialdehyde and chitosan succinate containing the Lucentis drug


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Аннотация

A spectral-luminescent study of the hydrogel formed by the crosslinking of chitosan succinate and hyaluronic acid dialdehyde (HAD) macromolecules, which is a dosage form of the Lucentis drug (active ingredient, ranibizumab), has been conducted. The individual fluorescence (FL) spectra of Lucentis (λmax = 336 nm), HAD (λmax = 328 and 438 nm), and the hydrogel (λmax = 396 nm) have been obtained. An analysis of these spectra suggests the participation of carbonyl groups and proteins contained in HAD in its gelation with chitosan succinate. The diffusion of Lucentis from the hydrogel into a physiological solution was studied by a FL method to demonstrate the high prolonged-release properties of the new dosage form.

Авторлар туралы

S. Ostakhov

Ufa Institute of Chemistry

Хат алмасуға жауапты Автор.
Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

R. Kayumova

Ufa Institute of Chemistry

Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

R. Vildanova

Ufa Institute of Chemistry

Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

N. Sigaeva

Ufa Institute of Chemistry

Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

I. Khusnitdinov

Ufa Eye Research Institute

Email: ostahov@anrb.ru
Ресей, Ufa, 450008 Bashkortostan

S. Kolesov

Ufa Institute of Chemistry

Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

S. Khursan

Ufa Institute of Chemistry

Email: ostahov@anrb.ru
Ресей, Ufa, 450054 Bashkortostan

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