Мақаланы E-mail арқылы жіберу Biomarkers of prostate cancer sensitivity to the Sendai virus
- Авторлар: Belova A.A.1, Sosnovtseva A.O.1,2, Lipatova A.V.1, Njushko K.M.3, Volchenko N.N.3, Belyakov M.M.3, Sudalenko O.V.3, Krasheninnikov A.A.3, Shegai P.V.3, Sadritdinova A.F.1,3, Fedorova M.S.1, Vorobjov N.V.3, Alekseev B.Y.3, Kaprin A.D.3, Kudryavtseva A.V.1,3
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Мекемелер:
- Engelhardt Institute of Molecular Biology
- Pirogov Russian National Research Medical University
- National Medical Research Radiological Center
- Шығарылым: Том 51, № 1 (2017)
- Беттер: 80-88
- Бөлім: Molecular Cell Biology
- URL: https://journal-vniispk.ru/0026-8933/article/view/162962
- DOI: https://doi.org/10.1134/S0026893317010046
- ID: 162962
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Metastatic prostate cancer is often associated with either primary or intractable castration-resistant prostate cancer (CRPC), thus justifying the search for entirely new ways of treatment. Oncolytic viruses are able to selectively induce the death of tumor cells without affecting normal cells. A murine Sendai virus has potential to be used as an oncolytic agent. However, tumors vary in their sensitivity to different viruses, prompting us to attempt to identify corresponding biomarkers that reflect the interaction of cancer cells and the virus. Here, we show that the sensitivity of primary prostatic adenocarcinoma cell lines to Sendai virus strain (SeVM) vary substantially. Using quantitative PCR, we evaluated expression levels of genes that encode RIG-1-like and Toll-like receptors (TLRs) in cell lines and showed that the levels of mRNAs that encode TLR3 and TLR7 correlate with a degree of sensitivity of the cells to Sendai virus. The lines with lower levels of TLR3 and TLR7 expression are more sensitive to the virus.
Негізгі сөздер
Авторлар туралы
A. Belova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991
A. Sosnovtseva
Engelhardt Institute of Molecular Biology; Pirogov Russian National Research Medical University
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991; Moscow, 117997
A. Lipatova
Engelhardt Institute of Molecular Biology
Хат алмасуға жауапты Автор.
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991
K. Njushko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
N. Volchenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
M. Belyakov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
O. Sudalenko
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
A. Krasheninnikov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
P. Shegai
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
A. Sadritdinova
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991; Moscow, 125284
M. Fedorova
Engelhardt Institute of Molecular Biology
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991
N. Vorobjov
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
B. Alekseev
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
A. Kaprin
National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 125284
A. Kudryavtseva
Engelhardt Institute of Molecular Biology; National Medical Research Radiological Center
Email: lipatovaanv@gmail.com
Ресей, Moscow, 119991; Moscow, 125284
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