Quantification of Hexamethylenediamide Bis( N -Monosuccinyl-L-Seryl-L-Lysine) (GSB-106) in the Blood Plasma by HPLC–MS

O. G. Grybakina; N. B. Lopatina; E. V. Blynskaya; P. O. Bochkov; R. V. Shevchenko; A. A. Litvin; G. B. Kolyvanov; V. P. Zherdev; S. E. Kondakov

doi:10.3103/S0027131419030052

Quantification of Hexamethylenediamide Bis(N-Monosuccinyl-L-Seryl-L-Lysine) (GSB-106) in the Blood Plasma by HPLC–MS

Authors: Grybakina O.G.¹, Lopatina N.B.², Blynskaya E.V.¹, Bochkov P.O.¹, Shevchenko R.V.¹, Litvin A.A.¹, Kolyvanov G.B.¹, Zherdev V.P.¹, Kondakov S.E.³
Affiliations:
1. Zakusov Research Institute of Pharmacology
2. Sechenov University
3. Department of Chemistry, Moscow State University
Issue: Vol 74, No 3 (2019)
Pages: 143-145
Section: Article
URL: https://journal-vniispk.ru/0027-1314/article/view/163930
DOI: https://doi.org/10.3103/S0027131419030052
ID: 163930

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Abstract

The technique of the quantitative determination of GSB-106 in the blood plasma of rats is developed and validated. The analysis is performed by HPLC–MS. The method is linear in the range of 50 to 1000 ng/mL. The GSB-106 recovery from blood plasma was 82.15%. The lower limit of quantification was 50 ng/mL.