Effect of Pluronic F-127 on the photosensitizing activity of tetraphenylporphyrins in organic and aqueous phases


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Аннотация

The solubilization of hydrophobic porphyrin photosensitizers (PPSes) to obtain corresponding water-soluble forms is an important line of modern antimicrobial photodynamic therapy. It is shown that a triblock copolymer of ethylene and propylene oxides, Pluronic F-127, one of the most nontoxic and effective polymer surface active substances (SASes), can be used for the conversion of hydrophobic tetraphenylporphyrin (TPP) and monosubstituted and tetrasubstituted hydroxy, amino, and nitro TPPs into water-soluble forms. It is found that Pluronic has a substantially higher solubilizing affinity (defined as the minimum molar concentration of an SAS required for the complete migration of porphyrin with a specific molar concentration to the aqueous phase) toward monosubstituted TPPs than to corresponding tetrasubstituted porphyrins. It is shown that with Pluronic in the organic phase, the activity of tetraphenylporphyrin in a test reaction of the oxidation of anthracene is higher than that of its monosubstituted and tetrasubstituted derivatives. In an aqueous medium, the activity of solubilized mono derivatives of TPP is comparable to that of unsubstituted TPP and is higher than the activity of the corresponding tetra derivatives of TPP.

Авторлар туралы

M. Savko

Semenov Institute of Chemical Physics

Хат алмасуға жауапты Автор.
Email: msavko@mail.ru
Ресей, Moscow, 117977

N. Aksenova

Semenov Institute of Chemical Physics

Email: msavko@mail.ru
Ресей, Moscow, 117977

A. Akishina

Semenov Institute of Chemical Physics

Email: msavko@mail.ru
Ресей, Moscow, 117977

O. Khasanova

Semenov Institute of Chemical Physics

Email: msavko@mail.ru
Ресей, Moscow, 117977

N. Glagolev

Semenov Institute of Chemical Physics

Email: msavko@mail.ru
Ресей, Moscow, 117977

V. Rumyantseva

Moscow Technological University

Email: msavko@mail.ru
Ресей, Moscow, 119454

K. Zhdanova

Moscow Technological University

Email: msavko@mail.ru
Ресей, Moscow, 119454

A. Spokoinyi

State Scientific Center of Laser Medicine

Email: msavko@mail.ru
Ресей, Moscow, 121165

A. Solov’eva

Semenov Institute of Chemical Physics

Email: msavko@mail.ru
Ресей, Moscow, 117977

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