Pilot experience in the treatment of poor-prognosis primary diffuse large-B-cell lymphosarcoma of the bones and soft tissues with a modified program NHL-BFM-90

Anna Konstantinovna Morozova; Морозова Анна Константиновна; Evgeniy Evgen'evich Zvonkov; Звонков Евгений Евгеньевич; Aleksandra Mikhaylovna Kremenetskaya; Кременецкая Александра Михайловна; Aminat Umuraskhabovna Magomedova; Магомедова Аминат Умурасхабовна; Tat'yana Nikiforovna Obukhova; Обухова Татьяна Никифоровна; Vasiliy Evgen'evich Mamonov; Мамонов Василий Евгеньевич; Elena Aleksandrovna Baryakh; Барях Елена Александровна; Andrey Vladimirovich Gubkin; Губкин Андрей Владимирович; Aleksandra Ivanovna Lukina; Лукина Александра Ивановна; Ekaterina Alekseevna Ilyushkina; Илюшкина Екатерина Алексеевна; Olesya Sergeevna Fink; Финк Олеся Сергеевна; Tat'yana Nikolaevna Perestoronina; Пересторонина Татьяна Николаевна; Sergey Kirillovich Kravchenko; Кравченко Сергей Кириллович; A K Morosova; Morosova A K; E E Zvonkov; Zvonkov E E; A M Kremenetskaya; Kremenetskaya A M; A U Magomedova; Magomedova A U; T N Obukhova; Obukhova T N; V E Mamonov; Mamonov V E; E A Baryakh; Baryakh E A; A V Gubkin; Gubkin A V; A I Lukina; Lukina A I; E A Ilyushkina; Ilyushkina E A; O S Fink; Fink O S; T N Perestoronina; Perestoronina T N; S K Kravchenko; Kravchenko S K

Pilot experience in the treatment of poor-prognosis primary diffuse large-B-cell lymphosarcoma of the bones and soft tissues with a modified program NHL-BFM-90

作者: Morozova A.K.¹, Zvonkov E.E.¹, Kremenetskaya A.M.¹, Magomedova A.U.¹, Obukhova T.N.¹, Mamonov V.E.¹, Baryakh E.A.¹, Gubkin A.V.¹, Lukina A.I.¹, Ilyushkina E.A.¹, Fink O.S.¹, Perestoronina T.N.¹, Kravchenko S.K.¹, Morosova AK¹, Zvonkov EE¹, Kremenetskaya AM¹, Magomedova AU¹, Obukhova TN¹, Mamonov VE¹, Baryakh EA¹, Gubkin AV¹, Lukina AI¹, Ilyushkina EA¹, Fink OS¹, Perestoronina TN¹, Kravchenko SK¹
隶属关系:
1. ГУ Гематологический научный центр РАМН
期: 卷 81, 编号 7 (2009)
页面: 61-65
栏目: Editorial
URL: https://journal-vniispk.ru/0040-3660/article/view/30405
ID: 30405

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Aim. To evaluate efficacy of intensive modified program NHL-BFM-90 (mNHL-BFM-90) in adult poor-prognosis patients with diffuse large B-cell lymphosarcoma (DLBCL) of the bones and soft tissues.
Material and methods. The mNHL-BFM-90 program was used in the treatment of 3 male and 2 female patients aged 17-69 years (median 42 years). Four patients had DLBCL of the bones and one patient - DLBCL of the soft tissues. All the patients had tumors more than 10 cm in size. B-symptoms, a high concentration of lactate dehydrogenase (LDG) were registered in 3 patients. One patient had stage IE by Ann-Arbor, two - stage IIE (involvement of regional lymph nodes), two - stage ME (multiple bone lesions). A total of 4-6 blocks of polychemotherapy according to mNHL-BFM-90 program were performed.
Results. Complete remissions were achieved in all the patients. They had no recurrences after 6 to 20 month (median 13 months) follow-up.
Conclusion. Positive results of the program mNHL-BFM-90 in poor-prognosis patients with DLBCL of the bones and tissues necessitate further studies of this therapy.

关键词

diffuse large B-cell lymphosarcoma, bones, soft tissues, high-dose polychemotherapy

参考

Воробьев А. И., Кременецкая А. М., Харазишвили Д. В. Диффузные В-крупноклеточные лимфосаркомы. В кн.: Воробьев А. И. (ред.). Руководство по гематологии. 3-е изд. М.: "Ньюдиамед"; 2002; т. 2: 57-62.
Воробьев А. И. Атлас "Опухоли лимфатической системы". М.: Ньюдиамед; 2007. 167-205.
Gill P., Wenger D., Inwards D. Primary lymphomas of bone. Clin. Lymphoma & Myeloma 2005; 6 (2): 140-142.
Ramadan K. M., Shenkier T., Sehn L. H. et al. 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann. Oncol. 2007; l8: l29-135.
Travis W. D., Banks P. M., Reiman H. M. Primary extranodal soft tissue lymphome of the extremities. Am. J. Surg. Pathol. 1987; 11: 359-366.
Parker F., Jackson H. Primary reticulum cell sarcoma of bone. Surg. Gynecol. Obstet. 1939; 68: 45-53.
Oberling C. Les reticulosarcomes et les reticuloendotheliosarcomes de la moelle osseuse (sarcomes D'Ewing), Bull. Cancer (Paris) 1928; 17: 259-296.
Freeman C., Berg J. W., Cutler S. J. Occurrence and prognosis of extranodal lymphomas. Cancer (Philad.) 1972; 29: 252- 260.
Beggs I. Primary muscle lymphoma. Clin. Radiol. 1997; 52: 203-212.
Lee V. S. et al. Primary muscle lymphoma: clinical and imaging findings. Radiology 1997; 203: 237-244.
Grunshaw N. D., Chalmers A. G. Skeletal muscle lymphoma. Clin. Radiol. 1992; 45: 399-400.
Ludwig K. Muskuloskelettale lymphome. Radiologe 2002; 42: 988-992.
Hwang S. Imaging of lymphoma of musculoskeletal system. Radiol. Clin. N. Am. 2008; 46: 379-396.
Ruzek K. A., Wenger D. E. The multiple faces of lymphoma of the musculoskeletal system. Skeletal Radiol. 2004; 33: 1-8.
Lewis V. O., Primus G., Anastasi J. et al. Oncologic outcomes of primary lymphomas of bone in adults. Clin. Orthop. 2003; 415: 90-97.
Lones M. A., Perkins Sh. L., Sposto R. et al. Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a children's cancer group report. J. Clin. Oncol. 2002; 20 (9): 2293-2301.
Murphy S., Fairclough D., Hutchison R. et al. Non-Hodgkin's lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. J. Clin. Oncol. 1989; 7(2): 186-193.
Barbieri E., Cammellin C., Mauro F. et al. Primary Non-Hodgkln lymphoma of the bone treatment and analysis of prognostic factors. Int. J. Radiat. Oncol. Biol. Phys. 2004; 59 (3): 760-764.
Звонков Е. Е., Кременецкая А. М., Кравченко С. К. и др. Эффективность консервативной терапии лимфосаркомы желудка. Тер. арх. 2008; 7: 18-27.
Reiter A., Schrappe M., Ludwig W.-D. et al. Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin-Frankfurt-Munster Group Trial NHL-BFM-90. Blood 1999; 94 (10): 3294- 3297.
Барях Е. А., Звонков Е. Е., Кременецкая А. М. и др. Лечение беркиттоподобной лимфомы взрослых. Тер. арх. 2006; 7: 53-58.
Zvonkov E., Baryakh E., Krasilnikova B. et al. Modified NHL-BFM-90 program in primary gastric diffuse large B-cell lymphoma (PGDLBCL) with adverse prognostic factors. Leukemia Res. 2007; 31: S91.
Кравченко С. К., Барях Е. А., Замятина В. И. и др. Высокодозная терапия лимфомы Беркитта у больных старше 40 лет. Тер. арх. 2008; 7: 9-18.
Fairbanks R. K., Bonner J. A., Inwards C. Y. et al. Treatment stage IE primary lymphoma of bone. Int. J. Radiat. Oncol. Biol. Phys. 1994; 28: 363-372.
Marhal D. T., Amdur R. J., Scarborough M. T. et al. Stage IE primary non Hodgkin lymphoma of bone. Clin. Orthop. 2002; 26 (4): 216-222.
Fidas P., Spiro I., Scobczak M. L. et al. Long-term results of combined modality therapy in primary bone lymphomas. Int. J. Radiat. Oncol. Biol. Phys. 1999; 45: 1213-1238.

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Pilot experience in the treatment of poor-prognosis primary diffuse large-B-cell lymphosarcoma of the bones and soft tissues with a modified program NHL-BFM-90

全文:

详细

关键词

作者简介

Anna Morozova

Evgeniy Zvonkov

Aleksandra Kremenetskaya

Aminat Magomedova

Tat'yana Obukhova

Vasiliy Mamonov

Elena Baryakh

Andrey Gubkin

Aleksandra Lukina

Ekaterina Ilyushkina

Olesya Fink

Tat'yana Perestoronina

Sergey Kravchenko

A Morosova

E Zvonkov

A Kremenetskaya

A Magomedova

T Obukhova

V Mamonov

E Baryakh

A Gubkin

A Lukina

E Ilyushkina

O Fink

T Perestoronina

S Kravchenko

参考

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