Pathogenetic and therapeutic approaches to the correction of neurocognitive disorders in patients with chronic brucellosis

Aim. Evaluation of the efficacy of Cytoflavin in the correction of mild cognitive disorders in patients with chronic brucellosis.

Materials and methods. A total of 40 patients with inactive forms of chronic brucellosis who sought medical care were examined, including 17 men (42.5%) and 23 women (57.5%), with an average age of 46.4±3.7 years. In Group 1 patients received intravenous infusions of Cytoflavin for 10 days as a neuroprotector, and in Group 2 – "active placebo" (100 ml of 0.9% sodium chloride solution). Study design: open-label, randomized, comparative, random sampling.

Results. It has been established that inactive forms of chronic brucellosis are accompanied by damage to the nervous system with the development of mild (predementia) cognitive impairment and deterioration in quality of life. In the group of patients receiving Cytoflavin, there was a statistically significant decrease in the severity of neurological deficit, a significant increase in the total score of the MoCA test, and a statistically significant improvement in the indicators of both physical and psychological health components according to the scales of the SF-36 questionnaire. No side effects were recorded during the use of Cytoflavin in the patients of the study group, which indicates good tolerability of the drug.

Conclusion. The prescription of a course of infusion neuroprotective therapy with Cytoflavin contributes to a significant clinical improvement in patients with inactive chronic brucellosis with significant positive dynamics of cognitive functioning parameters assessed using MoCA testing and health indicators according to the SF-36 questionnaire.