Plasma levels of cell adhesion molecules in normal pregnancy and preeclampsia
- Authors: Shelekhin A.P.1, Baev O.R.2,1, Andreev Y.V.3, Sadekova A.A.2, Krasnyi A.M.2
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Affiliations:
- I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Health Department
- Issue: No 11 (2023)
- Pages: 71-77
- Section: Original Articles
- URL: https://journal-vniispk.ru/0300-9092/article/view/275110
- DOI: https://doi.org/10.18565/aig.2023.200
- ID: 275110
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Abstract
Objective: The objective of this study was to determine the levels of soluble forms of cell adhesion molecules (sVCAM-1, sICAM-1, sE-selectin, and sP-selectin) in the maternal blood of women with preeclampsia (PE) and compare them to levels in women with normal pregnancies, taking into account the severity and phenotype of PE.
Materials and methods: A prospective case-control study was conducted involving peripheral blood plasma samples collected from women with normal pregnancies (n=30) and preeclampsia (n=50). Multiplex assay was used to determine the concentrations of sVCAM-1, sICAM-1, sE-selectin, and sP-selectin.
Results: The concentration of sVCAM-1 in peripheral blood was significantly higher in women with preeclampsia than in those with uncomplicated pregnancies (p<0.001). Furthermore, sVCAM-1 levels were significantly higher in severe than in moderate preeclampsia (p=0.014). In addition, sVCAM-1 levels were higher in patients with early-onset than in those with late-onset preeclampsia. However, no statistically significant differences were observed in the levels of sICAM-1, sE-selectin, or sP-selectin.
Conclusion: Our study revealed increased sVCAM-1 levels in the peripheral blood of pregnant women with preeclampsia. This elevation correlates with the severity of the disease, suggesting the involvement of this molecule in the development of preeclampsia. The differences in sVCAM-1 levels between early- and late-onset preeclampsia suggest different pathogenic mechanisms underlying these two conditions.
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##article.viewOnOriginalSite##About the authors
Artemiy P. Shelekhin
I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
Author for correspondence.
Email: dr.shelekhin@gmail.com
ORCID iD: 0000-0002-7682-1329
postgraduate student
Russian Federation, MoscowOleg R. Baev
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)
Email: o_baev@oparina4.ru
ORCID iD: 0000-0001-8572-1971
Dr. Med. Sci., Professor, Head of the 1st maternity, Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology
Russian Federation, 117997, Moscow, Ac. Oparina str., 4, 119991, Moscow, Trubetskaya str., 8-2Yuliy V. Andreev
N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Health Department
Email: AndreevUV@sklif.mos.ru
ORCID iD: 0000-0001-8151-940X
PhD, Senior Researcher at the Department of Biotechnologies and Transfusiology
Russian Federation, 129090, Moscow, B. Sukharevskaya sqr., 3Alsu A. Sadekova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: sialsad@gmail.com
ORCID iD: 0000-0003-4726-7477
PhD, Senior Researcher at the Cytology Laboratory
Russian Federation, 119991, Moscow, Trubetskaya str., 8-2Alexey M. Krasnyi
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_krasnyi@oparina4.ru
ORCID iD: 0000-0001-7883-2702
PhD, Head of the Cytology Laboratory
Russian Federation, 119991, Moscow, Trubetskaya str., 8-2References
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