Complex therapy of bacterial vaginosis during pregnancy
- Авторлар: Tyutyunnik V.L.1, Mikhailova O.I.1, Kan N.E.1, Mirzabekova D.D.1
-
Мекемелер:
- Academician V.I. Kulakov National Medical Research Centre of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Шығарылым: № 7 (2023)
- Беттер: 126-132
- Бөлім: Exchange of Experience
- URL: https://journal-vniispk.ru/0300-9092/article/view/274617
- DOI: https://doi.org/10.18565/aig.2023.172
- ID: 274617
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Objective: To present own experience of complex treatment of bacterial vaginosis during pregnancy.
Materials and methods: The study included 46 patients with a pregnancy at 22–36 weeks’ gestation with confirmed bacterial vaginosis. All patients were divided into two equal groups: women of group 1 received treatment with an antibiotic in com-bination with the immunomodulatory medication Superlymph, patients of group 2 received only antibiotic therapy. Efficacy was evaluated by the analysis of clinical manifestations, microbiological and microscopic examination of vaginal dis-charge, vaginal pH, pro-inflammatory cytokines.
Results: In both groups there was a decrease in the number of epithelial cells and leukocytes during the treatment, key cells were not detected after the treatment; however, the improvement was more significant in group 1. There was also a de-crease of the titer in both groups. But despite the treatment, the average titer of Gardnerella vaginalis was >104 CFU/ml in 17.4% (n=4). The growth of Lactoba-cillus spp. in both groups was evidence of the effectiveness of the therapy while the value of this microorganism was higher in group 1. Moreover, there was a statisti-cally significant decrease of pro-inflammatory cytokines to normal values in the main group. The most favorable results for obstetric and perinatal outcomes (preterm rupture of membranes, preterm labor, asphyxia, intrauterine infection of newborns, etc.) were obtained in group 1.
Conclusion: Immunomodulatory medication Superlymph combined with antibacte-rial drugs improves the effectiveness of the treatment for bacterial vaginosis during pregnancy.
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Толық мәтін
##article.viewOnOriginalSite##Авторлар туралы
Victor Tyutyunnik
Academician V.I. Kulakov National Medical Research Centre of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Хат алмасуға жауапты Автор.
Email: tioutiounnik@mail.ru
ORCID iD: 0000-0002-5830-5099
SPIN-код: 1963-1359
Scopus Author ID: 56190621500
ResearcherId: B-2364-2015
Professor, MD, PhD, Leading Researcher of Research and Development Service
Ресей, 117997, Moscow, Ac. Oparina str., 4Olga Mikhailova
Academician V.I. Kulakov National Medical Research Centre of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: omikhaylova@gmail.com
ORCID iD: 0000-0001-7569-8704
PhD, Researcher, 2 Maternity Department
Ресей, 117997, Moscow, Ac. Oparina str., 4Natalia Kan
Academician V.I. Kulakov National Medical Research Centre of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: kan-med@mail.ru
ORCID iD: 0000-0001-5087-5946
SPIN-код: 5378-8437
Scopus Author ID: 57008835600
ResearcherId: B-2370-2015
MD, PhD, Deputy Director of Science
Ресей, 117997, Moscow, Ac. Oparina str., 4Dzhamilia Mirzabekova
Academician V.I. Kulakov National Medical Research Centre of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: Jamilya1705@yandex.ru
ORCID iD: 0000-0002-2391-3334
graduate student
Ресей, 117997, Moscow, Ac. Oparina str., 4Әдебиет тізімі
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