Email this article Method for Synthesis of (±)-Entecavir
- Authors: Valiullina Z.R.1, Ivanova N.A.1, Miftakhov M.S.1
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)
- Issue: Vol 61, No 5 (2025)
- Pages: 566-571
- Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://journal-vniispk.ru/0514-7492/article/view/318342
- DOI: https://doi.org/10.31857/S0514749225050072
- ID: 318342
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Abstract
Starting from (±)-lactonediol Corey, a practical route for the synthesis of (±)-Entecavir was developed, the key step of which is the preparation of (1R*,3R*,4S*)-4-(1-ethoxyethoxy)-3-[(1-ethoxyethoxy) methyl]-2-methylenecyclopentanol by oxidative decarboxylation of {(1S*,2R*,3S*,5R*)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-(1-ethoxyethoxy)-2-[(1-ethoxyethoxy)methyl]cyclopentyl}acetic acid with lead tetraacetate.
About the authors
Z. R. Valiullina
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)
Email: valiullina.zulya@mail.ru
prosp. Oktyabrya, 69, Ufa, 450054 Russia
N. A. Ivanova
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)prosp. Oktyabrya, 69, Ufa, 450054 Russia
M. S. Miftakhov
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)prosp. Oktyabrya, 69, Ufa, 450054 Russia
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