Email this article The prevention of postnatal endometriosis in puerperae with different degree of infection risk with implementation of application form of sorbent agent
- Authors: Tirskaia Y.I.1, Barinov S.V1, Pianova L.G2, Blauman S.I3
-
Affiliations:
- The Omsk state medical academy of Minzdrav of Russia
- The institute of problems of processing of hydrocarbons of the Siberian branch of the Russian academy of sciences
- The clinical maternity hospital N 6
- Issue: Vol 21, No 3 (2015)
- Pages: 36-42
- Section: Articles
- URL: https://journal-vniispk.ru/0869-2106/article/view/38269
- DOI: https://doi.org/10.17816/rmj38269
- ID: 38269
Cite item
Full Text
Abstract
The first stage of study included determination of risk factors of postnatal pyo-septic complications and development of scale of evaluation of degree of infection risk. The second stage of study included implementation of cohort, prospective, randomized research. The sampling included 176 puerperae with infection risk. The observed women were separated on groups depending on degree of infection risk according the developed scale. The puerperae of comparison group received common antibacterial prevention by cephalosporin of third generation. The puerperae of main group during postnatal period besides prevention with antibiotics, were additionally injected into uterine cavity a contact-type form of sorbent VNIITU-1. The effectiveness of prevention was evaluated by determination of the level of proinflammatory and anti-inflammatory cytokines in aspirate from uterine cavity at first and third day and occurrence of growth of pathogenic flora. In puerperae of comparison group after common antibiotic prevention, growth of pathogenic flora in uterine cavity persisted. This process contributed into increasing of activity of local proinflammatory cytokines (IL-1β), acute-phase protein lactoferrin against the background of decreasing of activity of anti-inflammatory cytokines (IL-10, IL-RAIL). It also testified high activity of local macrophages and absence of tendency of suppression of inflammatory cascade. The proposed mode of prevention of postnatal endometriosis in puerperae with infection risk by intrauterine injection of porous carbonic applicator VNIITU-1 is more effective due to stimulation of full value elimination of agents and their excreted toxins from uterine cavity. Additionally, blocking of local proinflammatory cascade and intensification of involutorial processes of myometrium against the background of restoration of hemodynamics occurs.
Full Text
##article.viewOnOriginalSite##About the authors
Yuliya I. Tirskaia
The Omsk state medical academy of Minzdrav of Russia
Email: yulia.tirskaya@yandex.ru
MD, PhD 644043 Omsk, Russia
S. V Barinov
The Omsk state medical academy of Minzdrav of Russia644043 Omsk, Russia
L. G Pianova
The institute of problems of processing of hydrocarbons of the Siberian branch of the Russian academy of sciences644040 Omsk, Russia
S. I Blauman
The clinical maternity hospital N 6644043 Omsk, Russia
References
- Серов В.Н. Пути снижения акушерской патологии. Акушерство и гинекология. 2007; 5: 8-12.
- Селихова М.С., Костенко Т.И., Селихов А.В., Котовских М.В. К вопросу о распространенности послеродовых инфекционных осложнений. В кн.: Материалы IX Всероссийского форума "Мать и дитя". М.: 2007: 229-30.
- Радзинский В.Е. Акушерская агрессия. М.: Статус презенс; 2011.
- Абрамченко В.В. Гнойно-септическая инфекция в акушерстве и гинекологии. СПб.; 2005.
- Горин В.С., Серов В.Н., Бирюкова Л.А. Оптимизация диагностики и лечения послеродового эндометрита. Российский вестник акушера-гинеколога. 2009; 1: 15.
- Анохова Л.И., Загородняя Э.Д., Дашкевич О.Ю. Профилактика эндометрита после кесарева сечения методом эндоваскулярного лазерного облучения. В кн.: Материалы VII Российского форума "Мать и дитя". 2005: 17-8.
- Жаркин Н.А., Кен-Амоа С. Профилактика и лечение эндометрита после кесарева сечения методом вагинальной рефлексотерапии. Акушерство и гинекология. 2007; 4: 57-9.
- Краснопольский В.И., Буянова С.Н., Щукина Н.А. Акушерский сепсис как репродуктивная проблема. Акушерство и гинекология. 2007; 3: 38-42.
- American Academy of Pediatrics and American College of Obstetricians and Gynecologists. Obstetric and medical complications. American Academy of Pediatrics and American College of Obstetricians and Gynecologists. In: Guidelines for perinatal care. 6th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2008: 175-204.
- Кучеренко М.А. Применение Трифамокса (амоксициллина/сульбактама) для профилактики инфекционных осложнений при кесаревом сечении. Consilium Medicum. 2007; 9 (6): 35-8.
- Тютюнник В.Л., Шмаков Р.Г., Кан Н.Е., Баев О.Р., Балушкина А.А. Федеральные клинические рекомендации. Антибиотикопрофилактика при абдоминальном родоразрешении. М.: Российское общество акушеров-гинекологов ФГБУ "Научный Центр акушерства, гинекологии и перинатологии им. В.И. Кулакова" Минздрава России; 2013.
- Tita A., Rouse D., Blackwel S. et al. Evolving concepts in antibiotic prophylaxis for cesarean delivery: A systematic review. Obstet. Gynecol. 2009; 113 (3): 675-82.
- Сухих Г.Т., Ушкалова Е., Шифман Е.М., Хилькевич Е.Г. Антибиотикопрофилактика при операции кесарева сечения. Врач. 2011; 1: 3-6.
- Committee opinion no. 465: antimicrobial prophylaxis for cesarean delivery: timing of administration. Obstet. Gynecol. 2010; 116 (3): 791-2.
- Филлипов С.И., Путалова И.Н., Низовой К.А., Павлов С.С., Малюк А.И., Бархатов С.И. Способ лечения распространенного гнойного перитонита. Патент РФ № 2306927, 2007.
Supplementary files
