From tradition to innovation: advantages of ultra-brief pulse electroconvulsive therapy compared to short-pulse stimulation
- Authors: Bani Younes M.M.1, Arbuzova A.R.1, Ulanova A.A.1
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Affiliations:
- Saratov State Medical University named after V.I. Razumovsky
- Issue: Vol LVII, No 3 (2025)
- Pages: 218-225
- Section: Reviews
- URL: https://journal-vniispk.ru/1027-4898/article/view/349007
- DOI: https://doi.org/10.17816/nb679990
- EDN: https://elibrary.ru/IPCIGB
- ID: 349007
Cite item
Abstract
The origins of electroconvulsive therapy (ECT) trace back to antiquity — as early as the 1st century AD, Roman doctors used electric rays applied to patients’ heads to induce seizures and alleviate symptoms of migraine and depression. For many centuries, convulsive seizures were believed to beneficially affect patients mental states. ECT was first implemented in 1938 by Italian scientist Professor Ugo Cerletti and his assistant Lucio Bini, yet this biological treatment method remains relevant in clinical practice today and is used in managing various mental disorders. This article examines the advantages of ultra-brief pulses during ECT compared to short-pulse methodology. Short-pulse currents used in ECT devices can induce cognitive impairments in patients. Therefore, in recent years, ultra-brief pulse ECT has been introduced as an alternative approach. This review is based on a comprehensive analysis of contemporary scientific literature, including peer-reviewed articles from international (Scopus, PubMed, Web of Science) and Russian (eLibrary, CyberLeninka) databases. The analysis demonstrates that ultra-brief pulse ECT reduces the frequency of cognitive impairments in patients and shows better tolerability, justifying further investigation of the efficacy and safety of ultra-brief pulse ECT in psychiatric patients.
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##article.viewOnOriginalSite##About the authors
Manaf M. M. Bani Younes
Saratov State Medical University named after V.I. Razumovsky
Author for correspondence.
Email: manaf.bani@yandex.ru
ORCID iD: 0009-0008-9255-6933
Russian Federation, Saratov
Anna R. Arbuzova
Saratov State Medical University named after V.I. Razumovsky
Email: annettarbuzova@yandex.ru
ORCID iD: 0009-0001-2978-0691
SPIN-code: 8299-6247
Russian Federation, Saratov
Anastasiya A. Ulanova
Saratov State Medical University named after V.I. Razumovsky
Email: anastasia_u113@bk.ru
ORCID iD: 0009-0007-6507-9409
Russian Federation, Saratov
References
- Nelson AI. Electroconvulsive therapy in psychiatry, narcology and neurology. Moscow: BINOM. Laboratoriya znanii; 2005. 368 р. (In Russ.) ISBN: 5-94774-249-7
- Arbuzova AR, Sizov SV. The use of electroconvulsive therapy in the treatment of schizophrenia. In: Week of Russian science (WeRuS-2024): a collection of materials from the XIII All-Russian Science Week with international participation, dedicated to the National Donor Day. Saratov: Saratovskii gosudarstvennyi meditsinskii universitet im. V.I. Razumovskogo; 2024. Р. 823–824. (In Russ.) EDN: SGTCDR
- Arbuzova AR, Sizov SV. Biological methods of treatment of schizophrenia: insulinocomatous, antropinocomatous and electroconvulsive. In: Young people and science: results and perspectives: collection of materials of the All-Russian scientific and practical conference of students and young scientists with international participation. Saratov: Saratovskii gosudarstvennyi meditsinskii universitet im. V.I. Razumovskogo; 2023. Р. 42–43. (In Russ.) EDN: UHJYND
- Bykov YuV, Bekker RA. Minimizing ECT cognitive side effects: current clinical reality and future perspectives (a review of the literature with author comments and recommendations) part II (practical). Siberian Journal of Life Sciences and Agriculture. 2016;(12):200–272. doi: 10.12731/wsd-2016-12-200-272 EDN: XGYTWP
- Sizov SV, Barylnik YuB, Vorontsov OV, et al. The effects of electroconvulsive therapy on state of cognitive functions and possibilities for optimization of mental disorders treatment using ECT. Bulletin of Neurology, Psychiatry and Neurosurgery. 2014;(6):17–25. EDN: TLJAXR
- Valentine M, Keddie KM, Dunne D. A comparison of techniques in electro-convulsive therapy. Br J Psychiatry. 1968;114(513):989–996. doi: 10.1192/bjp.114.513.989
- Weiner RD, Rogers HJ, Davidson JR, Squire LR. Effects of stimulus parameters on cognitive side effects. Ann N Y Acad Sci. 1986;462:315–325. doi: 10.1111/j.1749-6632.1986.tb51266.x
- Tsukarzi EE. Modern methods of brain stimulation: achievements and perspectives for use. Social and Clinical Psychiatry. 2013;23(1):93–99. EDN: QADGPJ
- Loo CK, Katalinic N, Martin D, Schweitzer I. A review of ultrabrief pulse width electroconvulsive therapy. Ther Adv Chronic Dis. 2012;3(2):69–85. doi: 10.1177/2040622311432493
- Mayur P, Harris A. Comparison of antidepressant effects between brief and ultrabrief pulse unilateral electroconvulsive therapy: brief report of a randomized double-blind trial. J ECT. 2011;27(4):e59–60. doi: 10.1097/YCT.0b013e318218945e
- Spaans HP, Kho KH, Verwijk E, et al Efficacy of ultrabrief pulse electroconvulsive therapy for depression: a systematic review. J Affect Disord. 2013;150(3):720–726. doi: 10.1016/j.jad.2013.05.072
- Loo CK, Garfield JB, Katalinic N, et al. Speed of response in ultrabrief and briefpulsewidthrightunilateral ECT. Int J Neuropsychopharmacol. 2013;16(4):755–761. doi: 10.1017/S1461145712000806
- Galletly C, Paterson T, Burton C. A report on the introduction of ultrabrief pulse width ECT in a private psychiatric hospital. J ECT. 2012;28(1):59. doi: 10.1097/YCT.0b013e318221b42e
- Verwijk E, Spaans HP, Comijs HС, et al. Relapse and long-term cognitive performance after briefpulse or ultrabriefpulse right unilateral electroconvulsive therapy: A multicenter naturalistic follow up. J Affect Disord. 2015;184:137–144. doi: 10.1016/j.jad.2015.05.022
- Tor PC, Bautovich A, Wang MJ, et al. A systematic review and meta-analysis of brief versus ultrabrief right unilateral electroconvulsive therapy for depression. J Clin Psychiatry. 2015;76(9):e1092–1098.doi: 10.4088/JCP.14r09145
- Verwijk E, Comijs HC, Kok RM, et al. Neurocognitive effects after brief pulse and ultrabrief pulse unilateral electroconvulsive therapy for major depression: a review. J Affect Disord. 2012;140(3):233–243. doi: 10.1016/j.jad.2012.02.024
- Loo C, Sheehan P, Pigot M, Lyndon W. A report on mood and cognitive outcomes with right unilateral ultrabrief pulse width (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT. J Affect Disord. 2007;103(1-3):277–281. doi: 10.1016/j.jad.2007.06.012
- Loo CK, Sainsbury K, Sheehan P, Lyndon B. A comparison of RUL ultrabrief pulse (0.3 ms) ECT and standard RUL ECT. Int J Neuropsychopharmacol. 2008;11(7):883–890. doi: 10.1017/S1461145708009292
- Loo CK, Katalinic N, Smith DJ, et al. A randomized controlled trial of brief and ultrabrief pulse right unilateral electroconvulsive therapy. Int J Neuropsychopharmacol. 2014;18(1):pyu045. doi: 10.1093/ijnp/pyu045
- Martin D, Katalinic N, Hadzi-Pavlovic D, et al Cognitive effects of brief and ultrabrief pulse bitemporal electroconvulsive therapy: a randomised controlled proof-of-concept trial. Psychol Med. 2020;50(7):1121–1128. doi: 10.1017/S0033291719000989
- Mayur P, Byth K, Harris A. Autobiographical and subjective memory with right unilateral high-dose 0.3-millisecond ultrabrief-pulse and 1-millisecond brief-pulse electroconvulsive therapy: a double-blind, randomized controlled trial. J ECT. 2013;29(4):277–282. doi: 10.1097/YCT.0b013e3182941baf
- Kellner CH, Husain MM, Knapp RG, et al Right unilateral ultrabrief pulse ECT in geriatric depression: phase 1 of the PRIDE study. Am J Psychiatry. 2016;173(11):1101–1109. doi: 10.1176/appi.ajp.2016.15081101
- Avrutsky GYa, Neduva AA. Treatment of mentally ill. Moscow: Meditsina; 1988. 528 р. (In Russ.) ISBN: 5-225-00052-5
- Sizov SV, Barylnik YuB, Filippova NV. Approaches to electroconvulsive therapy for patients with treatment-resistant schizophrenia and concomitant cardiovascular diseases. Bulletin of Neurology, Psychiatry and Neurosurgery. 2019;(10):70–78. doi: 10.33920/med-01-1910-10 EDN: HCPWTY
- Rhoads JC, Votolato NA, Young JL, Gilchrist RH. The successful use of right unilateral ultra-brief pulse electroconvulsive therapy in an adolescent with catatonia. Brain Stimul. 2010;3(1):51–53. doi: 10.1016/j.brs.2009.07.003
- Wong VKH, Tor PC, Martin DM, et al Effectiveness and cognitive changes with ultrabrief right unilateral and other forms of electroconvulsive therapy in the treatment of mania. J ECT. 2019;35(1):40–43. doi: 10.1097/YCT.0000000000000519
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