CATALASE ACTIVITY OF CATALYTIC ANTIBODIES IN SCHIZOPHRENIA
- 作者: Ermakov E.A.1,2, Smirnova L.P.3, Krotenko N.M.3, Semke A.V.3, Buneva V.N.2, Nevinsky G.A.2
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隶属关系:
- Novosibirsk State University
- Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
- Mental Health Research Institute
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 242-244
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119658
- DOI: https://doi.org/10.31857/S102872210006588-1
- ID: 119658
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详细
In this work, the ability of catalytic antibodies (abzymes) in patients with schizophrenia and healthy donors to catalyze the decomposition of hydrogen peroxide was investigated. The polyclonal IgG in patients with schizophrenia and healthy donors was found to have catalase activity, and the activity of patient’s IgG was 1.7 times higher. The heterogeneity of abzymes with catalase activity by affi nity to metal ions, pH optimum, kinetic parameters is shown. A possible antioxidant function of catalytic antibodies with catalase activity is discussed.
作者简介
E. Ermakov
Novosibirsk State University;Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
编辑信件的主要联系方式.
Email: evgeny_ermakov@mail.ru
Assistant of Department of Molecular Biology and Biotechnology, Novosibirsk State University, Novosibirsk, Russia; Senior Laboratory Assistant, Laboratory of Repair Enzymes,
Novosibirsk
俄罗斯联邦L. Smirnova
Mental Health Research Institute
Email: fake@neicon.ru
PhD, Senior Researcher, Laboratory of Molecular Genetics and Biochemistry,
Tomsk
俄罗斯联邦N. Krotenko
Mental Health Research Institute
Email: fake@neicon.ru
Ph.D., Senior Researcher, Laboratory of Molecular Genetics and Biochemistry,
Tomsk
俄罗斯联邦A. Semke
Mental Health Research Institute
Email: fake@neicon.ru
MD, Professor, Deputy Director for Scientifi c and Medical Work, Head of the Department of Endogenous Disorders,
Tomsk
俄罗斯联邦V. Buneva
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: fake@neicon.ru
Dr. Sc., prof., Chief Researcher of the Laboratory of Repair Enzymes,
Novosibirsk
俄罗斯联邦G. Nevinsky
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Email: fake@neicon.ru
Dr. Sc., prof., Head of the Laboratory of Repair Enzymes,
Novosibirsk
俄罗斯联邦参考
- Yao J.K., Reddy R. Oxidative Stress in Schizophrenia: Pathogenetic and Therapeutic Implications. Antioxid. Redox Signal. 2011, 15(7), 1999–2002.
- Steullet P., Cabungcal J.H., Monin A., Dwir D., O’Donnell P., Cuenod M., Do K. Q. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? Schizophrenia research. 2016, 176(1), 41–51.
- Nevinsky G. A., Buneva V. N. Natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases. The Scientific World Journal, 2010, 10, 1203–1233.
- Ермаков Е. А., Толмачева А. С., Смирнова Л. П., Иванова С. А., Бунева В. Н., Невинский Г. А. Особенности окислительно-восстановительных, амилазной и АТРазной активностей IgG антител из крови больных шизофренией. Российский иммунологический журнал, 2017, 11(4), 627–640.
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