THE REGULATION OF TREG DIFFERENTIATION BY ENDOGENOUS MELATONIN DURING PREGNANCY
- 作者: Glebezdina N.S.1, Olina A.A.2, Nekrasova I.V.1, Kuklina E.M.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, UB RAS
- Perm State Medical University named after academician E. A. Wagner of the Ministry of healthcare of the Russian Federation
- 期: 卷 20, 编号 2 (2017)
- 页面: 285-286
- 栏目: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119895
- ID: 119895
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详细
The role of endogenous melatonin in the regulation of the process of regulatory T cells (Treg) differentiation during the gestation period has been studied. The difference in the regulation of this process by the hormone was shown in non-pregnant and pregnant women. The positive effect of melatonin on the cells in vitro mediated by signals from membrane receptors for the hormone in response to polyclonal activation was revealed at pregnancy.
作者简介
N. Glebezdina
Institute of Ecology and Genetics of Microorganisms, UB RAS
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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A. Olina
Perm State Medical University named after academician E. A. Wagner of the Ministry of healthcare of the Russian Federation
Email: noemail@neicon.ru
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I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, UB RAS
Email: noemail@neicon.ru
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E. Kuklina
Institute of Ecology and Genetics of Microorganisms, UB RAS
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Wu L., Luo L.- H., Zhang Y.- X., Li Q., Xu B. et al. Alteration of Th 17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy. Re-prod. Biol. Endocrinol. 2014, 12, 74.
- Steinborn A., Schmitt E., Kisielewicz A., Rechenberg S., Seissler N. et al. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin. Exp. Immunol. 2012, 167(1), 84-98.
- Lardone P. J., Guerrero J. M., Fernandez-Santos J. M., Rubio A., Martin-Lacave I. et al. Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor. J. Pineal. Res. 2011, 51(4), 454-462.
- Farez M. F., Mascanfroni I. D., Mendez-Huergo S. P., Yeste A., Murugaiyan G. et al. Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell. 2015, 162 (6), 1338-1352.
- Ziegler S. F., Buckner J. H. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 2009, 11(5), 594-598.
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