Evaluation of specific T cell immune response to SARS-CoV-2 in COVID-19 infection and following Gam-COVID-Vac vaccine prophylaxis
- 作者: Plekhova N.G.1, Sitdikova T.S.1, Dubiy A.A.1, Mikhailov A.O.1, Prosekovа E.V.1
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隶属关系:
- Pacific State Medical University
- 期: 卷 25, 编号 3 (2022)
- 页面: 267-274
- 栏目: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/1028-7221/article/view/120190
- DOI: https://doi.org/10.46235/1028-7221-1111-EOS
- ID: 120190
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全文:
详细
An aberrant immune response during SARS-CoV-2 infection has been shown to determine the clinical features, disease severity, and progression of COVID-19 infection. This work aimed for comprehensive assessment of the immune response by comparative evaluation of diagnostic significance of the antibodies to RBD domain of the SARS-CoV-2 spike protein, as well as detection of effector CD4+ and CD8+T cells specific to SARS-CoV-2 antigens. The study was performed in unvaccinated persons, healthy individuals vaccinated with Gam-COVID-Vac, and in the patients who have had COVID-19 infection. We have found that IgG antibodies to the RBD domain of the SARS-CoV-2 spike protein are detectable at a frequency of 73% to 92% of cases in vaccinated persons and COVID-19 reconvalescents. The numbers of effector CD4+ and CD8+T lymphocytes responding to stimulation with SARS-CoV-2 antigens by producing the IFNã cytokine varied depending on the introduced antigen and tended to be higher in vaccinated individuals. In non-vaccinated healthy persons who contacted with COVID-19 patients, T cell response to the SARS-CoV-2 nucleoproteins was revealed. For adequate assessment of antiviral and post-vaccination immune response to COVID-19, it would be necessary to study not only humoral immune response by the presence of antibodies, but also functionally active specific T lymphocytes directed for SARS-CoV-2 protein antigens.
作者简介
N. Plekhova
Pacific State Medical University
编辑信件的主要联系方式.
Email: pl_nat@hotmail.com
PhD, MD (Biology), Associate Professor, Head, Central Research Laboratory
俄罗斯联邦, VladivostokT. Sitdikova
Pacific State Medical University
Email: pl_nat@hotmail.com
PhD (Medicine), Lecturer, Department of Clinical Laboratory Diagnostics, General and Clinical Immunology
俄罗斯联邦, VladivostokA. Dubiy
Pacific State Medical University
Email: olleariu.a@yandex.ru
Student, Faculty of Public Health
俄罗斯联邦, VladivostokA. Mikhailov
Pacific State Medical University
Email: pl_nat@hotmail.com
PhD (Medicine), Research Associate, Central Research Laboratory
俄罗斯联邦, VladivostokE. Prosekovа
Pacific State Medical University
Email: pl_nat@hotmail.com
PhD, MD (Medicine), Professor, Head, Department of Clinical Laboratory Diagnostics, General and Clinical Immunology
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