Clinical and immunological characteristics of post-covid patients with infectious immunopathology syndrome
- 作者: Dobrynina M.A.1,2,3, Zurochka A.V.1,3, Zurochka V.A.1,3
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隶属关系:
- Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
- State Research Center of the Russian Federation, A. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency
- Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections “Virome” Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing
- 期: 卷 27, 编号 3 (2024)
- 页面: 689-698
- 栏目: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/1028-7221/article/view/267541
- DOI: https://doi.org/10.46235/1028-7221-16845-CAI
- ID: 267541
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详细
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has caused global morbidity and high mortality worldwide. Today it is known that, despite recovery from COVID-19, confirmed by both laboratory and instrumental diagnostic methods, many patients, regardless of the severity of the disease, suffer from a significant deterioration in health and increased exacerbations of chronic diseases. During examinations by attending physicians, they note fatigue, an increase in cases of acute respiratory viral infections per year, an increase in relapses of skin diseases such as furunculosis, pyoderma, exacerbation of pulmonary pathologies, pathologies of the urinary tract of inflammatory origin, as well as chronic infectious diseases such as herpesvirus and human papillomavirus infections, which occur for the first time or are characterized by frequent relapses no less than six months after recovery from acute COVID-19. Such persistent post-infectious consequences are known as post-COVID syndrome. SARS-CoV-2 infection is accompanied by damage to both the acquired and innate immune systems. In previous work, we determined the role of B cells, cytotoxic T lymphocytes, natural killer cells and the regulatory properties of CD46, as well as its involvement in the processes of viral entry into the cell. In this study, we studied the relationship of immune disorders of these factors of innate and acquired immunity with the clinical manifestations of post-COVID infectious syndrome in this category of patients and the severity of lung damage in these patients during the acute period of COVID-19. The results of the study showed that in some patients more than six months after suffering from COVID-19, the following was revealed: in patients who had a coronavirus infection without lung damage, no violations of the innate and acquired parts of the immune system were detected. In addition, significant differences were identified between clinical manifestations of diseases with increasing cases of relapses or newly identified after clinical recovery from an acute COVID-19 infection, depending on the phenotype of immune status disorders.
作者简介
M. Dobrynina
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences; State Research Center of the Russian Federation, A. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency; Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections “Virome” Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing
Email: iip@iip.uran.ru
PhD (Medicine), Research Associate, Laboratory of Immunopathophysiology, Senior Research Associate, Laboratory of Transmissible Viral Diseases, Associate Professor, Department of Therapy, University of Innovation and Continuing Education
俄罗斯联邦, Yekaterinburg; Moscow; YekaterinburgA. Zurochka
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences; Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections “Virome” Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing
Email: mzurochka@mail.ru
PhD, MD (Medicine), Professor, Honored Worker of Science of the Russian Federation, Leading Research Associate, Laboratory of Immunopathophysiology, Leading Research Associate, Laboratory of Transmissible Viral Diseases
俄罗斯联邦, Yekaterinburg; YekaterinburgV. Zurochka
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences; Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections “Virome” Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing
编辑信件的主要联系方式.
Email: mzurochka@mail.ru
PhD, MD (Medicine), Senior Research Associate, Laboratory of Immunopathophysiology, Senior Research Associate, Laboratory of Transmissible Viral Diseases
俄罗斯联邦, Yekaterinburg; Yekaterinburg参考
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