| Dublin Core |
PKP Metadata Items |
Metadata for this Document |
| 1. |
Title |
Title of document |
REASONABILITY OF THE PRIMARY TUMOR REMOVAL IN METASTATIC BREAST CANCER PATIENTS AT INITIAL PRESENTATION |
| 2. |
Creator |
Author's name, affiliation, country |
E. V Chernova; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
V. A Khaylenko; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
E. V Artamonova; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
K. P Laktionov; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
O. P Trofimova; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
L. V Manzjuk; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 2. |
Creator |
Author's name, affiliation, country |
D. V Komov; N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences |
| 3. |
Subject |
Discipline(s) |
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| 3. |
Subject |
Keyword(s) |
breast; disseminated cancer; surgery |
| 4. |
Description |
Abstract |
Treatment of patients with newly diagnosed metastatic breast cancer is based on the drug and radiation therapy. Extraction of the primary tumor is generally not recommended. We examined the effects of surgical treatment on survival of 91 patients with metastatic primary breast cancer observed in the RCRC. NN Blokhin, for the period from 1999 to 2009. All women received systemic therapy with or without radiation therapy. Excision of the primary tumor was performed in 91 cases, in 106 cases (control group) the operation was not performed. Removal of the primary tumor in patients with primary - metastatic breast cancer with ECOG 0-1 has shown to be an independent prognostic factor, which significantly improves overall survival and progression-free survival. Multivariate analysis revealed a significant increase in overall survival and progression-free survival in those cases where the operation was carried out after successful systemic therapy with achievement of partial response, compared with those who underwent surgery in the first stage (p < 0,05). In addition, the long-term results of surgical treatment of patients with newly diagnosed metastatic breast cancer affect the number of metastases, the number of affected organs and positive hormone receptor status of the tumor (p < 0.05). However, given the many other factors that can affect the long-term results of surgical treatment of patients with primary metastatic breast cancer, it is advisable to conduct a prospective study. |
| 5. |
Publisher |
Organizing agency, location |
Eco-Vector |
| 6. |
Contributor |
Sponsor(s) |
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| 7. |
Date |
(DD-MM-YYYY) |
15.04.2013
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| 8. |
Type |
Status & genre |
Peer-reviewed Article |
| 8. |
Type |
Type |
Research Article |
| 9. |
Format |
File format |
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| 10. |
Identifier |
Uniform Resource Identifier |
https://journal-vniispk.ru/1028-9984/article/view/39969 |
| 10. |
Identifier |
Digital Object Identifier (DOI) |
10.17816/onco39969 |
| 10. |
Identifier |
Digital Object Identifier (DOI) (PDF (Rus)) |
10.17816/onco39969-26518 |
| 11. |
Source |
Title; vol., no. (year) |
Russian Journal of Oncology; Vol 18, No 2 (2013) |
| 12. |
Language |
English=en |
ru |
| 13. |
Relation |
Supp. Files |
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| 14. |
Coverage |
Geo-spatial location, chronological period, research sample (gender, age, etc.) |
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| 15. |
Rights |
Copyright and permissions |
Copyright (c) 2013 Eco-Vector
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