电邮这篇文章 Exosomal microRNAs in Diagnosis of Colorectal Cancer
- 作者: Serbaeva M.S.1,2, Vorobyev S.A.3, Ruksha T.G.2, Zukov R.A.1,2
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隶属关系:
- Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
- Professor Voino-Yasenetsky Krasnoyarsk State Medical University
- Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Sciences
- 期: 卷 30, 编号 1 (2025)
- 页面: 17-24
- 栏目: Original Study Articles
- URL: https://journal-vniispk.ru/1028-9984/article/view/313544
- DOI: https://doi.org/10.17816/onco643119
- EDN: https://elibrary.ru/WJALWU
- ID: 313544
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详细
BACKGROUND: Global statistics show that the incidence and mortality rates of colorectal cancer are rising, particularly among young adults (< 50 years of age) in developed and developing countries. This requires the search for non-invasive colorectal cancer biomarkers.
AIM: The study aimed to identify exosomal microRNA targets for diagnosing colorectal cancer in patients over and under 50 years of age.
METHODS: Next-generation sequencing was performed on plasma samples from 10 patients (6 men and 4 women) between the ages of 32 and 65 diagnosed with colorectal cancer followed by hydrodynamic diameter analysis of exosomes measured by dynamic light scattering in triplicate.
RESULTS: Nine microRNAs that are characteristic of colorectal cancer were identified in exosomes: miR-26b, miR-124-1, miR-518b, miR-520d, miR-518d, miR-612, miR-1283-1, and miR-1260 for patients > 50 years, and miR-4510 for patients < 50 years.
CONCLUSION: The non-invasive diagnosis of colorectal cancer using exosomal microRNAs shows high potential across age groups. However, challenges in reproducing this technique in routine clinical practice require further research.
作者简介
Margarita Serbaeva
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary; Professor Voino-Yasenetsky Krasnoyarsk State Medical University
编辑信件的主要联系方式.
Email: serbaeva94@mail.ru
ORCID iD: 0009-0007-3268-2535
SPIN 代码: 4662-4362
俄罗斯联邦, Krasnoyarsk; Krasnoyarsk
Sergey Vorobyev
Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Sciences
Email: yekspatz@yandex.ru
SPIN 代码: 7747-0299
MD, Cand. Sci. (Chemistry)
俄罗斯联邦, KrasnoyarskTatiana Ruksha
Professor Voino-Yasenetsky Krasnoyarsk State Medical University
Email: tatyana_ruksha@mail.ru
ORCID iD: 0000-0001-8142-4283
SPIN 代码: 5412-2148
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, KrasnoyarskRuslan Zukov
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary; Professor Voino-Yasenetsky Krasnoyarsk State Medical University
Email: zukov_rus@mail.ru
ORCID iD: 0000-0002-7210-3020
SPIN 代码: 3632-8415
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Krasnoyarsk; Krasnoyarsk参考
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