Influence of temperature on the rhombic shape of paracetamol molecular crystals


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The method of differential scanning ellipsometry has been used to study the influence of heating on the rhombic shape of paracetamol molecular crystals. Rhombic molecular paracetamol crystals have been synthesized in vacuum from the vapor phase of paracetamol as a result of complex transformation, which includes a second-order transition that gives rise to a pretransition phase. It has been found that these crystals contain monoclinic nuclei, which favor the form I-to-form II polymorphic transformation during heating.

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A. Belyaev

St. Petersburg State Chemical Pharmaceutical Academy

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Email: Alexei.Belyaev@pharminnotech.com
俄罗斯联邦, ul. Prof. Popova 14, St. Petersburg, 197376

V. Rubets

St. Petersburg State Technological Institute

Email: Alexei.Belyaev@pharminnotech.com
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013

V. Antipov

St. Petersburg State Chemical Pharmaceutical Academy

Email: Alexei.Belyaev@pharminnotech.com
俄罗斯联邦, ul. Prof. Popova 14, St. Petersburg, 197376

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