New aspects of using biologically active thioterpenoids of pinane series

L. E. Nikitina; S. V. Kiselev; V. A. Startseva; O. A. Lodochnikova; A. A. Rakhmatullina; I. V. Fedyunina; I. R. Gilfanov

doi:10.1007/s11172-019-2515-2

New aspects of using biologically active thioterpenoids of pinane series

Authors: Nikitina L.E.¹, Kiselev S.V.¹, Startseva V.A.¹, Lodochnikova O.A.², Rakhmatullina A.A.³, Fedyunina I.V.¹, Gilfanov I.R.¹
Affiliations:
1. Kazan State Medical University
2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
3. Republican Blood Center
Issue: Vol 68, No 5 (2019)
Pages: 1031-1035
Section: Full Article
URL: https://journal-vniispk.ru/1066-5285/article/view/243376
DOI: https://doi.org/10.1007/s11172-019-2515-2
ID: 243376

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Abstract

Pinane sulfi de obtained by the addition of methyl hydrosulfanylacetate at the double bond of β-pinene inhibits platelet receptor activity. It inhibits completely platelet aggregation induced by adrenaline, ADP, collagen, arachidonic acid, and also reduces the eff ect of ristomycin. This compound inhibits both platelet and coagulation hemostasis, which allows one to use it for creation promising antiaggregation drugs and for stabilization blood products.