Email this article A new original approach to the design of anticancer drugs based on energy-rich quadricyclanes
- Authors: Dzhemilev U.M.1, Akhmetov A.R.1, Khuzin A.A.1, D’yakonov V.A.1, Dzhemileva L.U.1, Yunusbaeva M.M.1, Khalilov L.M.1, Tuktarov A.R.1
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Affiliations:
- Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
- Issue: Vol 68, No 5 (2019)
- Pages: 1036-1040
- Section: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/243377
- DOI: https://doi.org/10.1007/s11172-019-2516-1
- ID: 243377
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Abstract
Quadricyclane derivatives are shown for the first time to be promising for application as anticancer drugs. The efficiency of such cage compounds is mainly due to thermal action on cancer cells resulting from a C—C bond cleavage in quadricyclane on exposure to catalytic amounts of cisplatin Pt ions.
About the authors
U. M. Dzhemilev
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
A. R. Akhmetov
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
A. A. Khuzin
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
V. A. D’yakonov
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
L. U. Dzhemileva
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
M. M. Yunusbaeva
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
L. M. Khalilov
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
A. R. Tuktarov
Institute of Petroleum Chemistry and Catalysis, Russian Academy of Sciences
Author for correspondence.
Email: tuktarovar@gmail.com
Russian Federation, 141 prosp. Oktyabrya, Ufa, Republic of Bashkortostan, 450075
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