Мақаланы E-mail арқылы жіберу Biological activity of some sulfur- and selenium-containing spiro compounds
- Авторлар: Proshin A.N.1, Orlova M.A.2,3, Trofimova T.P.2,3
-
Мекемелер:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
- Шығарылым: Том 66, № 10 (2017)
- Беттер: 1931-1933
- Бөлім: Brief Communications
- URL: https://journal-vniispk.ru/1066-5285/article/view/241483
- DOI: https://doi.org/10.1007/s11172-017-1968-4
- ID: 241483
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Cytotoxicity to K-562 leukemia cell line of two spiro compounds containing selenium or sulfur atom in their structure were compared. 4-Fluorophenyl-(1-thia-3-azaspiro[5.5]undec-2-en-2-yl]amine hydrobromide was synthesized and characterized for the first time. It was found that the introduction of a sulfur atom is more promising for this biological model, since it leads to a 3-fold increase in the therapeutic index in the case of the sulfur-containing compound.
Авторлар туралы
A. Proshin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Ресей, 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Хат алмасуға жауапты Автор.
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; I ul. Samory Mashela, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; I ul. Samory Mashela, Moscow, 117997
Қосымша файлдар
