Synthesis of new selenium-containing analogs of phenozan acid

Resumo

Selenium-containing analogs of phenozan acid, [3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propylseleno]ethanoic and 3-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propylseleno]propanoic acids, were synthesized from bis-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]diselenide. The possibility of functionalization of the obtained compounds via the esterification and preparation of potassium salts was demonstrated. According to the in silico evaluation of acute toxicity towards rats, the synthesized compounds are low toxic and non-toxic substances.