1-chloroacetyloxindole(isatin) in reactions with some  N -nucleophiles. Unexpetedly easy cleavage of chloroacetyl group

A. V. Bogdanov; T. A. Kutuzova; D. B. Krivolapov; A. B. Dobrynin; V. F. Mironov

doi:10.1134/S1070363216030087

1-chloroacetyloxindole(isatin) in reactions with some N-nucleophiles. Unexpetedly easy cleavage of chloroacetyl group

Authors: Bogdanov A.V.¹, Kutuzova T.A.¹, Krivolapov D.B.¹, Dobrynin A.B.¹, Mironov V.F.¹
Affiliations:
1. Arbuzov Institute of Organic and Physical Chemistry
Issue: Vol 86, No 3 (2016)
Pages: 539-543
Section: Article
URL: https://journal-vniispk.ru/1070-3632/article/view/214172
DOI: https://doi.org/10.1134/S1070363216030087
ID: 214172

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Abstract

Reactions of 1-chloroacetyloxindole and 1-chloroacetylisatin with some secondary amines, Girard’s reagent T and thiourea were studied. All investigated reactions proceeded via cleavage of the acyl group to form 3-substituted isatin or oxindole derivatives.