Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity


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Resumo

Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains.

Sobre autores

D. Ashok

Green and Medical Chemistry Laboratory, Department of Chemistry

Autor responsável pela correspondência
Email: ashokdou@gmail.com
Índia, Hyderabad, 500007

M. Ziauddin

Green and Medical Chemistry Laboratory, Department of Chemistry; Department of Pharmaceutical Sciences, University College of Technology

Email: ashokdou@gmail.com
Índia, Hyderabad, 500007; Hyderabad, 500007

B. Lakshmi

Green and Medical Chemistry Laboratory, Department of Chemistry

Email: ashokdou@gmail.com
Índia, Hyderabad, 500007

M. Sarasija

Green and Medical Chemistry Laboratory, Department of Chemistry

Email: ashokdou@gmail.com
Índia, Hyderabad, 500007

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