Synthesis of prolyl-glutamate phosphoisostere

Аннотация

A method for the synthesis of prolyl-glutamate phosphoisostere by cyclic amidoalkylation of phosphonous acid containing a structural isostere of glutamic acid was developed. A combination of amide and carbonyl moieties in the 4-N-Cbz-aminobutyraldehyde molecule allows cyclization with in situ generation of a cyclic pyrrolidine Schiff base followed by its Arbuzov type phosphorylation.