Synthesis and biological activity of 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols

A. A. Aghekyan; G. G. Mkryan; A. S. Tsatinyan; O. S. Noravyan; G. V. Gasparyan

doi:10.1134/S1070428017030083

Synthesis and biological activity of 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols

Authors: Aghekyan A.A.¹, Mkryan G.G.¹, Tsatinyan A.S.¹, Noravyan O.S.¹, Gasparyan G.V.¹
Affiliations:
1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Issue: Vol 53, No 3 (2017)
Pages: 362-365
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/215895
DOI: https://doi.org/10.1134/S1070428017030083
ID: 215895

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Abstract

Treatment of 1-(4-chlorobenzylamino)-2-methylpropan-2-ol with concentrated sulfuric acid at 0°C gave 6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline which reacted with (aryloxymethyl)oxiranes to afford new propan-2-ol derivatives of the tetrahydroisoquinoline series, 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols. Some of the synthesized compounds or their hydrochlorides showed moderate adrenergic blocking and sympatholytic activities.