Synthesis of ortho-carboranyl derivatives of (S)-asparagine and (S)-glutamine


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Abstract

(S)-Asparagine and (S)-glutamine ortho-carboranyl derivatives with free amino and carboxy groups in the α-position were synthesized. By an example of Nγ-(1,2-dicarba-closo-dodecarboran-3-yl)-(S)-glutamine it was demonstrated that the developed synthetic approach carboranyl derivatives of amino acids allowed the preparation of optically pure isomers.

About the authors

D. A. Gruzdev

Postovsky Institute of Organic Synthesis, Ural Branch

Author for correspondence.
Email: gruzdev-da@ios.uran.ru
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990

G. L. Levit

Postovsky Institute of Organic Synthesis, Ural Branch

Email: gruzdev-da@ios.uran.ru
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990

V. A. Olshevskaya

Nesmeyanov Institute of Organoelement Compounds

Email: gruzdev-da@ios.uran.ru
Russian Federation, Moscow

V. P. Krasnov

Postovsky Institute of Organic Synthesis, Ural Branch

Email: gruzdev-da@ios.uran.ru
Russian Federation, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990

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