Email this article Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides
- Authors: Kavina M.A.1,2, Sizov V.V.1, Yakovlev I.P.2
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Affiliations:
- CHEM Ltd. Scientific and Production Company
- St. Petersburg State Chemical Pharmaceutical Academy
- Issue: Vol 53, No 6 (2017)
- Pages: 873-878
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/216354
- DOI: https://doi.org/10.1134/S1070428017060100
- ID: 216354
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Abstract
The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides.
About the authors
M. A. Kavina
CHEM Ltd. Scientific and Production Company; St. Petersburg State Chemical Pharmaceutical Academy
Email: vvsizov@list.ru
Russian Federation, ul. Zavodskaya 3, bld. 142, Kuz’molovskii, Leningrad oblast, 188663; ul. Prof. Popova 14, St. Petersburg, 197022
V. V. Sizov
CHEM Ltd. Scientific and Production Company
Author for correspondence.
Email: vvsizov@list.ru
Russian Federation, ul. Zavodskaya 3, bld. 142, Kuz’molovskii, Leningrad oblast, 188663
I. P. Yakovlev
St. Petersburg State Chemical Pharmaceutical Academy
Email: vvsizov@list.ru
Russian Federation, ul. Prof. Popova 14, St. Petersburg, 197022
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