Email this article Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles
- Authors: Seliverstova D.V.1, Suslonov V.V.1, Zarubaev V.V.2, Trifonov R.E.1
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Affiliations:
- St. Petersburg State University
- Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
- Issue: Vol 54, No 4 (2018)
- Pages: 633-638
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/217627
- DOI: https://doi.org/10.1134/S107042801804019X
- ID: 217627
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Abstract
Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.
About the authors
D. V. Seliverstova
St. Petersburg State University
Email: rost_trifonov@mail.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
V. V. Suslonov
St. Petersburg State University
Email: rost_trifonov@mail.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
V. V. Zarubaev
Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
Email: rost_trifonov@mail.ru
Russian Federation, ul. Mira 14, St. Petersburg, 197101
R. E. Trifonov
St. Petersburg State University
Author for correspondence.
Email: rost_trifonov@mail.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
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