Green Regioselective Synthesis of (Purin-6-yl)hydrazones


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Abstract

Some unique purine hydrazinylidene derivatives were synthesized by the regioselective reaction of 2,6-dichloropurine with hydrazine hydrate, followed by condensation with commercially available 1,3-dicarbonyl compounds according to a green chemistry approach. The structures of the synthesized compounds were confirmed by 1H and 13C NMR, IR, and mass spectra and elemental analyses. The regioselectivity of chlorine substitution in 2,6-dichloropurine was established by HMBC (Heteronuclear Multiple Bond Correlation) NMR technique.

About the authors

K. M. Kapadiya

School of Science, Department of Chemistry, Bio-Research and Characterization Laboratory

Author for correspondence.
Email: khushal_kapadiya06@yahoo.com
India, Rajkot, Gujarat

J. M. Dhalani

School of Science, Department of Chemistry, Bio-Research and Characterization Laboratory

Email: khushal_kapadiya06@yahoo.com
India, Rajkot, Gujarat

B. Y. Patel

B.V. Shah (Vadivihar) Science College, Department of Chemistry

Email: khushal_kapadiya06@yahoo.com
India, Wadhwancity, Surendranagar, Gujarat

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