Synthesis of functional derivatives of isothiazole and isoxazole basing on (5-arylizoxazol-3-yl)- and (4,5-dichloroisothiazol-3-yl)arylmethanol


Дәйексөз келтіру

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Аннотация

From (4,5-dichloroisothiazol-3-yl)phenylmethanol by Ritter reaction a substituted acetamide was synthesized that at hydrolysis with HCl afforded (4,5-dichloroisothiazol-3-yl)phenylmethylamine hydrochloride. By reaction of (5-arylisoxazol-3-yl)- and 4,5-dichloroisothiazol-3-yl)arylmethanol with thionyl chloride the corresponding (1,2-azol-3-yl)arylchloromethanes were obtained. At treatment with O- and N-nucleophiles chlorine atom in chloromethylеne fragment of obtained compounds was substituted by residues of benzylamine, morpholine, vanillin, and ethoxy group.

Авторлар туралы

V. Potkin

Institute of Physical Organic Chemistry of Belarus National Academy of Sciences

Хат алмасуға жауапты Автор.
Email: potkin@ifoch.bas-net.by
Белоруссия, ul. Surganova 13, Minsk, 220072

N. Bumagin

Lomonosov Moscow State University

Email: potkin@ifoch.bas-net.by
Ресей, Moscow, 119991

A. Kletskov

Institute of Physical Organic Chemistry of Belarus National Academy of Sciences

Email: potkin@ifoch.bas-net.by
Белоруссия, ul. Surganova 13, Minsk, 220072

S. Petkevich

Institute of Physical Organic Chemistry of Belarus National Academy of Sciences

Email: potkin@ifoch.bas-net.by
Белоруссия, ul. Surganova 13, Minsk, 220072

P. Kurman

Minsk Institute of Bioorganic Chemistry of Belarus National Academy of Sciences

Email: potkin@ifoch.bas-net.by
Белоруссия, Minsk

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