Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid

Zh. S. Arustamyan; R. E. Markaryan; A. A. Aghekyan; I. M. Nazaryan; A. G. Hakobyan; R. G. Paronikyan; N. S. Minasyan

doi:10.1134/S1070428019060095

Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid

作者: Arustamyan Z.S.¹, Markaryan R.E.¹, Aghekyan A.A.¹, Nazaryan I.M.¹, Hakobyan A.G.¹, Paronikyan R.G.¹, Minasyan N.S.²
隶属关系:
1. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
2. Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry
期: 卷 55, 编号 6 (2019)
页面: 796-799
栏目: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/220739
DOI: https://doi.org/10.1134/S1070428019060095
ID: 220739

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Alkaline hydrolysis of 1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carbonitrile gave the corresponding carboxylic acid which was converted to carbonyl chloride, and the latter reacted with N, N-di-alkylalkane-α,ω-diamines and dialkylaminoalkanols to afford new amino amides and amino esters which were isolated as hydrochlorides. Anticonvulsant activity of the synthesized compounds was studied.