Yamaguchi Esterification in the Synthetic Approaches to Precursors of Epothilone D Analogs

Аннотация

Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are related to the reactivity and molecular structure of the initial acid and alcohol components.