Synthesis and properties of ethyl 1-aryl-5-methyl-4-[1-(phenylhydrazinylidene)ethyl]-1H-pyrazole-3-carboxylates


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Ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates reacted with phenylhydrazine to give the corresponding hydrazones, ethyl 1-aryl-5-methyl-4-[1-(phenylhydrazinylidene)ethyl]-1H-pyrazole-3-carboxylates, which were converted to ethyl 1′-aryl-4-formyl-5′-methyl-1-phenyl-1H,1′H-3,4′-bipyrazole-3′-carboxylates by treatment with the Vilsmeier–Haack reagent. No indole derivatives were formed from the same hydrazones under the Fischer reaction conditions, but cyclization to 2-aryl-3,4-dimethyl-6-phenyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-ones was observed.

Sobre autores

M. Potopnyk

Ivan Franko National University of Lviv

Email: obushak@in.lviv.ua
Ucrânia, ul. Kyrylla i Mefodiya 6, Lviv, 79005

V. Matiichuk

Ivan Franko National University of Lviv

Email: obushak@in.lviv.ua
Ucrânia, ul. Kyrylla i Mefodiya 6, Lviv, 79005

M. Obushak

Ivan Franko National University of Lviv

Autor responsável pela correspondência
Email: obushak@in.lviv.ua
Ucrânia, ul. Kyrylla i Mefodiya 6, Lviv, 79005

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