Regioselective addition of primary amines to 2-halopyridine-3,4-dicarbonitriles. Synthesis of pyrrolo[3,4-c]pyridines

Resumo

Reaction of 2-chloropyridine-3,4-dicarbonitriles with primary amines in the presence of potassium carbonate in ethanol results in the fusion of pyrrole cycle and the formation of N¹-substituted 4-halo-1H-pyrrolo-[3,4-c]pyridine-1,3(2H)-diimines.