A Simple Efficient Click Synthesis of Novel Crown Ethers Containing 1,2,3-Triazole Moieties


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Resumo

Novel crown ether derivative containing 1,4-disubstituted-1,2,3-triazole moieties were synthesized. At the first step of the synthesis 4,13-diaza-18-crown-6 and 4-aminobenzo-15-crown-5 were converted into terminal alkynes, which were then subjected to copper(I)-catalyzed alkyne-azide coupling (CuAAC) in methylene chloride. This coupling reaction was performed according to the concept of click chemistry, using an Amberlyst A-21-supported copper(I) iodide catalyst.

Sobre autores

H. Elamari

Unit of Chemical and Biological Technologies for Health, UMR 8258 CNRS/U1022 Inserm, National Chemical Engineering Institute in Paris

Email: ouerghiabid@gmail.com
França, 11 rue Pierre et Marie Curie, Paris, 75005

A. Ouerghui

Unit of Functional Physiology and Valorization ofBioresources (UR17ES27), Higher Institute of Biotechnology of Beja; Laboratory of Organic Chemistry and Applications (Unit 05/UR/12-05), Faculty of Sciences of Bizerte

Autor responsável pela correspondência
Email: ouerghiabid@gmail.com
Tunísia, Beja, 9000; Bizerte, 7021

F. Ammari

Laboratory of Organic Chemistry and Applications (Unit 05/UR/12-05), Faculty of Sciences of Bizerte

Email: ouerghiabid@gmail.com
Tunísia, Bizerte, 7021

C. Girard

Unit of Chemical and Biological Technologies for Health, UMR 8258 CNRS/U1022 Inserm, National Chemical Engineering Institute in Paris

Email: ouerghiabid@gmail.com
França, 11 rue Pierre et Marie Curie, Paris, 75005

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