Thietanyl Protection in the Synthesis of 5-Aryloxy(sulfonyl)-3-bromo-1,2,4-triazoles
- Авторы: Khaliullin F.A.1, Klen E.E.1, Makarova N.N.1
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Учреждения:
- Bashkir State Medical University
- Выпуск: Том 54, № 12 (2018)
- Страницы: 1856-1859
- Раздел: Short Communications
- URL: https://journal-vniispk.ru/1070-4280/article/view/219636
- DOI: https://doi.org/10.1134/S1070428018120242
- ID: 219636
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Аннотация
Previously unknown 5-aryloxy- and 5-benzenesulfonyl-3-bromo-1H-1,2,4-triazoles have been synthesized starting from 3,5-dibromo-1,2,4-triazole by successive alkylation with 2-chloromethylthiirane, nucleophilic substitution of the 5-bromine atom by phenoxy or phenylsulfanyl group, oxidation of the thietane sulfur atom with hydrogen peroxide, and removal of the thietanyl protecting group by treatment with sodium ethoxide.
Об авторах
F. Khaliullin
Bashkir State Medical University
Email: klen_elena@yahoo.com
Россия, ul. Lenina 3, Ufa, Bashkortostan, 450008
E. Klen
Bashkir State Medical University
Автор, ответственный за переписку.
Email: klen_elena@yahoo.com
Россия, ul. Lenina 3, Ufa, Bashkortostan, 450008
N. Makarova
Bashkir State Medical University
Email: klen_elena@yahoo.com
Россия, ul. Lenina 3, Ufa, Bashkortostan, 450008
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