Synthesis of 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8,9-dihydropyrimido[5,4- e ]pyrrolo[1,2- c ]pyrimidine-1,3(2 H ,4 H )-diones and 2,4-dimethyl-9,10-dihydro-6λ 4 -pyrimido[5,4- d ]pyrrolo- [1,2- b ][1,2,6]thiadiazine-1,3,6(2 H ,4 H ,8 H )-trione

S. P. Gasparyan; M. V. Alexanyan; G. K. Harutyunyan; A. H. Martirosyan; H. M. Stepanyan; R. E. Muradyan; R. A. Tamazyan; A. G. Ayvazyan

doi:10.1134/S1070428016090177

Synthesis of 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8,9-dihydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3(2H,4H)-diones and 2,4-dimethyl-9,10-dihydro-6λ⁴-pyrimido[5,4-d]pyrrolo- [1,2-b][1,2,6]thiadiazine-1,3,6(2H,4H,8H)-trione

作者: Gasparyan S.P.¹, Alexanyan M.V.¹, Harutyunyan G.K.¹, Martirosyan A.H.¹, Stepanyan H.M.¹, Muradyan R.E.¹, Tamazyan R.A.², Ayvazyan A.G.²
隶属关系:
1. Mndzhoyan Institute of Fine Organic Chemistry Scientific Technological Center of Organic and Pharmaceutical Chemistry
2. Molecular Structure Research Center
期: 卷 52, 编号 9 (2016)
页面: 1348-1352
栏目: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/214979
DOI: https://doi.org/10.1134/S1070428016090177
ID: 214979

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详细

6-Imino-1,3-dimethyl-5-(pyrrolidin-2-ylidene)-5,6-dihydropyrimidine-2,4(1H,3H)-dione reacted with substituted benzoyl chlorides in the presence of triethylamine to give the corresponding 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8,9-dihydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3(2H,4H)-diones. Analogous reaction with thionyl chloride afforded 2,4-dimethyl-9,10-dihydro-6λ⁴-pyrimido[5,4-d]pyrrolo[1,2-b][1,2,6]-thiadiazine-1,3,6(2H,4H,8H)-trione.

作者简介

S. Gasparyan

Mndzhoyan Institute of Fine Organic Chemistry Scientific Technological Center of Organic and Pharmaceutical Chemistry

编辑信件的主要联系方式.
Email: g_sahak@yahoo.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014

M. Alexanyan

Mndzhoyan Institute of Fine Organic Chemistry Scientific Technological Center of Organic and Pharmaceutical Chemistry