Synthesis of Pyrrole Derivatives Promoted by Fe(ClO4)3/SiO2 as an Environmentally Friendly Catalyst

详细

N-Substituted pyrroles have been prepared in high isolated yields (702-99%) by the reaction of hexane-2,5-dione with amines or diamines in the presence of Fe(ClO₄)₃/SiO₂ at ambient temperature under solvent-free conditions. The experimental procedure involves simple operations, and the products are readily separated by short column chromatography. The same reaction of hexane-2,5-dione with amines containing electron-acceptor substituents, such as 4-nitroaniline, resulted in fair yields of pyrrole derivatives.