New Synthesis of Functionalized Nicotinamides

V. N. Khrustalev; V. G. Nenajdenko; I. V. Dyachenko; I. N. Kalashnik; V. D. Dyachenko; P. V. Dorovatovskii

doi:10.1134/S1070428019070194

New Synthesis of Functionalized Nicotinamides

作者: Khrustalev V.N.¹^,2, Nenajdenko V.G.³, Dyachenko I.V.⁴, Kalashnik I.N.⁴, Dyachenko V.D.⁴, Dorovatovskii P.V.¹
隶属关系:
1. “Kurchatov Institute” National Research Center
2. Peoples’ Friendship University of Russia
3. Faculty of Chemistry
4. Taras Shevchenko Lugansk National University
期: 卷 55, 编号 7 (2019)
页面: 1019-1033
栏目: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/220948
DOI: https://doi.org/10.1134/S1070428019070194
ID: 220948

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详细

An efficient method has been developed for the synthesis of 6-(alkylsulfanyl)-4-aryl(hetaryl)-N-aryl-5-cyano-2-methylpyridine-3-carboxamides by condensation of aromatic or heteroaromatic aldehydes with cyanothioacetamide and acetoacetanilides in the presence of triethylamine or morpholine, followed by S-alkylation.