NEUROEPIGENETICS OF BIPOLAR DIATHESIS: FROM THE SYNDROME OF MENTAL IMMUNE PROFICIENCY TO THE SYNDROME OF MENTAL IMMUNE DEFICIENCY

The aim of the article is the conceptual and methodological substantiation of epigenetic dysfunctions of mental immunity in the development of bipolar diathesis, represented by pre-nosological states and syndromes of mental immune proficiency (SMIP) and deficiency (SMID). In the onset of bipolar disorder (BD), these syndromes evolve into the manic phase (MPh) and/or depressive phase (DPh) of the disease. The allocated syndromes transgenerationally accumulate epigenetic labels of future possible BD and other mental diseases. Their pre-nosological functional diagnostics allows for screening and early prevention of mental disorders. These syndromes are the initial dysfunctional link in the development of the mental epidemiological cascade: mental epidemics - destructive mental epidemics - the pandemic of mental immune deficiency. Pandemic of mental immune deficiency is manifested by an increase in the prevalence of all mental and psychosomatic disorders, requiring a shift in the focus of preventive-corrective efforts to early pre-nosological fractals of the disease development. The clinical model of BD shows the pathoplastics and pathokinetics of mental immunity dysfunctions in the development of the disease. Mental immunity as an identity matrix predetermines the lateral mental constitution of the personality and the resources of its mental resilience. It is suggested to consider the clinic of mixed forms of BD as a manifestation of the ambidextral mental constitution. In the development of the BD, three pre-nosological fractals are distinguished: 1) predisposition - a bipolar family; 2) latent - bipolar diathesis (SMIP/SMID); 3) initial - the onset of the BD; and three nosological: 4) the full-scale clinical picture of BD (MPh and/or DPh); 5) chronization - the types and forms of the course; 6) outcome - somatopsychic and socio-moral complications.

bipolar diathesis, syndrome of mental immune proficiency, pandemic of mental immune deficiency, lateral mental constitution, dysfunctions of mental immunity