Arkhangelsk市成年居民的眼压水平及其与社会人口学特征、生活方式和健康状况的关系
- 作者: Sinayskaya M.A.1, Zelentsov R.N.1, Bebyakova N.A.1, Pechinkina N.I.1, Trofimova A.A.1, Kudryavtsev A.V.1
-
隶属关系:
- Northern State Medical University
- 期: 卷 32, 编号 4 (2025)
- 页面: 280-293
- 栏目: ORIGINAL STUDY ARTICLES
- URL: https://journal-vniispk.ru/1728-0869/article/view/314589
- DOI: https://doi.org/10.17816/humeco677157
- EDN: https://elibrary.ru/OUJLNS
- ID: 314589
如何引用文章
详细
论证。青光眼是导致人群致残的主要原因之一。眼内压 (intraocular pressure, IOP) 是青光眼发展的关键危险因素,因此对眼压的评估和监测具有重要意义。在青光眼筛查中,广泛采用气动眼压计法 (pneumotonometry) 进行IOP测量。
目的。明确俄罗斯欧洲北部地区成年居民的群体IOP参考值及其不同年龄段的变化,研究眼压与社会人口学特征、生活方式因素和健康指标之间的关系。
方法。对Arkhangelsk市45–74岁居民的随机样本(n=1223)进行检查,包括由眼科医生进行的检查和气动眼压测量。通过面对面访谈收集社会人口学和生活方式资料,通过医学检查收集健康状况数据。IOP参考值依据第5–95百分位数确定。IOP与各变量之间的关系通过多元线性回归进行评估,结果以回归系数B及其95%置信区间(CI)的形式呈现。
结果。总体人群的平均IOP为14.2 mmHg,其中男性为13.9 mmHg,女性为14.4 mmHg。明确了群体IOP的低正常(9–12 mmHg)、中等正常(12–16 mmHg)和高正常(16–20 mmHg)三个范围。IOP随年龄增长呈下降趋势,女性(p=0.007),男性(p=0.011)。IOP与男性性别(B=0.56;95% CI –0.94, –0.18)、为 Arkhangelsk Region 原住民身份(B=0.50;95% CI –0.83, –0.16)以及高等教育水平(B=0.40;95% CI –0.73, –0.06)呈负相关。在所分析的健康指标中,以下因素与IOP存在关联:高血压(B=0.56;95% CI 0.17, 0.94)、糖尿病(B=0.46;95% CI 0.03, 0.89)、血脂异常(B=0.36;95% CI 0.01, 0.71)、腹型肥胖(B=0.39;95% CI 0.31, 0.98)、甲状腺功能异常(B=0.42;95% CI 0.07, 0.77)、维生素D缺乏(B=0.76;95% CI 0.30, 1.22)以及血清总蛋白水平下降(B=–0.76;95% CI –1.43, –0.09)。
结论。本研究明确了俄罗斯欧洲北部45–74岁人群的IOP正常范围。研究发现,IOP水平随年龄增长而下降,男性、Arkhangelsk Region 原住民以及血清总蛋白水平较低者的眼压较低。而高血压、糖尿病、血脂异常、肥胖、甲状腺功能异常和维生素D缺乏则与IOP升高有关。
作者简介
Maria A. Sinayskaya
Northern State Medical University
Email: msinayskaya@inbox.ru
ORCID iD: 0009-0009-6587-7149
SPIN 代码: 1709-6124
MD, Cand. Sci. (Medicine), Associate Professor
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069Roman N. Zelentsov
Northern State Medical University
编辑信件的主要联系方式.
Email: zelentsovrn@gmail.com
ORCID iD: 0000-0002-4875-0535
SPIN 代码: 9312-3211
MD, Cand. Sci. (Medicine), Associate Professor
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069Natalya A. Bebyakova
Northern State Medical University
Email: nbebyakova@mail.ru
ORCID iD: 0000-0002-9346-1898
SPIN 代码: 6326-5523
Dr. Sci (Biology), Professor
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069Natalia I. Pechinkina
Northern State Medical University
Email: belova-8@mail.ru
ORCID iD: 0000-0001-9066-5687
SPIN 代码: 5164-4187
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069
Anastasia A. Trofimova
Northern State Medical University
Email: aa.trofimova@mail.ru
ORCID iD: 0000-0002-2248-6991
SPIN 代码: 8388-3638
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069
Alexander V. Kudryavtsev
Northern State Medical University
Email: alex.v.kudryavtsev@yandex.ru
ORCID iD: 0000-0001-8902-8947
SPIN 代码: 9296-2930
Ph.D.
俄罗斯联邦, 51 Troitskiy аve, Arkhangelsk, 163069参考
- Tham YC, Li X, Wong TY, et al. Global Prevalence of Glaucoma and Projections of Glaucoma Burden Through 2040: A Systematic Review and Meta-Analysis. Ophthalmology. 2014;121(11):2081-2090. doi: 10.1016/j.ophtha.2014.05.013
- Terminology and Guidelines for Glaucoma: European Glaucoma society.4th Edition. Savona, Italy; 2014.
- National guidance on glaucoma: for practitioners/ under the editorship of professor EA Egorov, professor YuS Astakhov, professor VP Erichev. Moscow: GEOTAR-Media; 2015. 456 p. (in Russ.)
- David R, Zangwill L, Stone D, Yassur Y. Epidemiology of Intraocular Pressure in a Population Screened for Glaucoma. Br. J. Ophthalmol. 1987;71(10):766-771. doi: 10.1136/bjo.71.10.766
- Fukuoka S, Aihara M, Iwase A, Araie M. Intraocular Pressure in an Ophthalmologically Normal Japanese Population. Acta Ophthalmol. 2008;86(4):434-439. doi: 10.1111/j.1600-0420.2007.01068.x
- Vijaya L, George R, Arvind H, et al. Central Corneal Thickness in Adult South Indians: The Chennai Glaucoma Study. Ophthalmology. 2010; 117(4):700-704. doi: 10.1016/j.ophtha.2009.09.025
- Xu L, Li J, Zheng Y, et al. Intraocular Pressure in Northern China in an Urban and Rural Population: the Beijing Eye Study. Am. J. Ophthalmol. 2005;140(5):913-915. doi: 10.1016/j.ajo.2005.04.050
- Onishchenko AL, Kolbasko AV, Shirina MA. Vnutriglaznoe Davlenie u Tubalarov — Korennogo Naseleniya Respubliki Altaj. Glaukoma. 2011; 4:49-51.
- Baboolal SO, Smit DP South African Eye Study (SAES): Ethnic Differences in Central Corneal Thickness and Intraocular Pressure. Eye (London, U. K.). 2018;32(4):749-756. doi: 10.1038/eye.2017.291
- Klein BE, Klein R, Linton KL. Intraocular Pressure in an American Community. The Beaver Dam Eye Study. Invest. Ophthalmol. Visual Sci. 1992;33(7):2224-2228. PMID: 1607232
- Wu SY, Leske MC. Associations With Intraocular Pressure in the Barbados Eye Study. Arch. Ophthalmol. 1997;115(12):1572-1576. doi: 10.1001/archopht.1997.01100160742012
- Lee MK, Cho SI, Kim H., et al. Epidemiologic Characteristics of Intraocular Pressure in the Korean and Mongolian Populations: the Healthy Twin and the GENDISCAN Study. Ophthalmology. 2012;119(3):450-457. doi: 10.1016/j.ophtha.2011.09.016
- Lin HY, Hsu WM, Chou P, et al. Intraocular Pressure Measured With a Noncontact Tonometer in an Elderly Chinese Population: The Shihpai Eye Study. Arch. Ophthalmol. 2005;123(3):381-386. doi: 10.1001/archopht.123.3.381
- Mori K, Ando F, Nomura H, et al. Relationship Between Intraocular Pressure and Obesity in Japan. Int. J. Epidemiol. 2000;29(4):661-666. doi: 10.1093/ije/29.4.661 EDN: IQCDEV
- Lee JS, Lee SH, Oum BS, et al. Relationship Between Intraocular Pressure and Systemic Health Parameters in a Korean Population. Graefe's Arch. Clin. Exp. Ophthalmol.. 2002;30(4):237-241. doi: 10.1046/j.1442-9071.2002.00527.x EDN: BADWYT
- Carel RS, Korczyn AD, Rock M, Goya I. Association Between Ocular Pressure and Certain Health Parameters. Am. J. Ophthalmol.. 1984;91(4):311-314. doi: 10.1016/S0161-6420(84)34282-8
- Levitsky SN, Bebyakova NA, Pechinkina NI, et al. Polymorphism of Genes Involved in the Regulation of Blood Pressure in Elderly Residents of the Arkhangelsk Region. Ekologiya cheloveka (Human Ecology). 2024;31(3):233–246 doi: 10.17816/humeco633999 EDN: QYDTVN
- Neufeld M, Rehm J, Bunova A, et al.; The 2019/2020 RUS-AUDIT Collaborators & the RUS-AUDIT Project Advisory Board. Validation of a Screening Test for Alcohol Use, the Russian Federation. Bull. W. H. O. 2021;99:496-505. doi: 10.2471/BLT.20.273227 EDN: KWLLPF
- SCORE2 working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur. Heart J. 2021;42(25):2439-2454. doi: 10.1093/eurheartj/ehab309 EDN: DGYBZW
- Maklakov AN. Eshche po Povodu Oftal'motonometrii. Hirurgicheskaya letopis'. 1893;4:1-11. (In Russ.)
- Mel'nik LS. O Normah Elastotonometricheskih Krivyh. Oftal'mologicheskij zhurnal. 1961;16(4):221. (In Russ.)
- Nesterov AP, Cherkunov BF. Elastotonometricheskie Issledovaniya Normal'nyh Glaz. Sb. nauch. tr. Kafedra glaznyh boleznej Kujbyshevskogo medinstituta. Kujbyshev; 1963:97-99. (In Russ.)
- Belorussov VK. O Normah Elastotonometricheskih Krivyh u Lic Raznyh Vozrastnyh Kategorij. Oftal'mologicheskij zhurnal. 1964;19(5):326-331. (In Russ.)
- Panina NB. O Normah Vnutriglaznogo Davleniya. Glaukoma i Drugie Zabolevaniya Glaz. Leningrad, 1971: 7-12. (In Russ.)
- Alekseev VN, Egorov EA, Martynova EB. O Raspredelenii Urovnej Vnutriglaznogo Davleniya v Normal'noj Populyacii. RMZh. Klinicheskaya oftal'mologiya. 2001;2(2):38-40. Available from: https://www.rmj.ru/articles/oftalmologiya/O_raspredelenii_urovney_vnutriglaznogo_davleniya_v_normalynoy_populyacii/?ysclid=mcg2sc6j3r26372234
- Egorov EA, Petrov SYu, Gorodnichij VV, Kuroedov AV, i dr. Tonometricheskoe vnutriglaznoe davlenie u vzroslogo naseleniya: populyacionnoe issledovanie. Nacional'nyj zhurnal glaukoma. 2020;19(2):39-50.
- Egorov EA, Erichev VP, Kuroedov AV, et al. Tonometric Intraocular Pressure Reference Values In Healthy Population. Nacional'nyj zhurnal glaukoma. 2018;17(2):91-98. doi: 10.25700/NJG.2018.02.09 EDN: UTLYOF
- Chan MP, Grossi CM, Khawaja AP, et al., UK Biobank Eye and Vision Consortium. Associations with Intraocular Pressure in a Large Cohort: Results from the UK Biobank. Ophthalmology. 2016;123(4):771-782. doi: 10.1016/j.ophtha.2015.11.031
- Leske MC, Connell AM, Wu SY, et al. Distribution of Intraocular Pressure. The Barbados Eye Study. Arch. Ophthalmol. 1997;115(8):1051-1057. doi: 10.1001/archopht.1997.01100160221012
- Han X, Niu Y, Guo X, et al. Age-Related Changes of Intraocular Pressure in Elderly People in Southern China: Lingtou Eye Cohort Study. PLoS One. 2016;11(3):e0151766. doi: 10.1371/journal.pone.0151766
- Bikbov MM, Kazakbaeva GM, Zainullin RM, et al. Intraocular Pressure and its Associations in a Russian Population: The Ural Eye and Medical Study. Am. J. Ophthalmol. 2019;204:130-139. doi: 10.1016/j.ajo.2019.02.030 EDN: LRJTCU
- Kim MJ, Park KH, Kim CY, et al. The Distribution of Intraocular Pressure and Associated systemic Factors in a Korean Population: The Korea National Health and Nutrition Examination Survey. Acta Ophthalmol. 2014;92(7):e507-513. doi: 10.1111/aos.12327
- Pakravan M, Javadi MA, Yazdani S, et al. Distribution of Intraocular Pressure, Central Corneal Thickness and Vertical Cup-to-Disc Ratio in a Healthy Iranian Population: The Yazd Eye Study. Acta Ophthalmol. 2017; 95(2):e144-e151. doi: 10.1111/aos.13231
- Landers J, Henderson T, Craig J. Distribution and Associations of Intraocular Pressure in Indigenous Australians within central Australia: The Central Australian Ocular Health Study. Clin. Exp. Ophthalmol. 2011; 39(7):607-613. doi: 10.1111/j.1442-9071.2011.02507.x
- Lantukh BB. Primary Glaucoma in the Indigenous Population of the Far North. Vestn. Ophthtalmol. 1985;1:60-62. (In Russ.) PMID: 3885552.
- Charaf W.M., , Siplivy V.I. Epidemiological aspects of glaucoma clinical progression,depending on social, economic, ethnic and geographic factors. Nacional'nyj zhurnal Glaukoma. 2014;13(1):68-76. EDN: SJVMTP
- Kiseleva OA, Robustova OV, Bessmertny AM, et al. Prevalence of primary glaucoma in representatives of different races and ethnic groups in Russia and in CIS. Oftal'mologiya. 2013;10(4):11-15. doi: 10.18008/1816-5095-2013-4-11-15
- Memarzadeh F, Ying-Lai M, Azen SP, Varma R, The Los Angeles Latino Eye Study Group. Associations with Intraocular Pressure in Latinos: The Los Angeles Latino Eye Study. Am. J. Ophthalmol. 2008;146(1):69-76. doi: 10.1016/j.ajo.2008.03.015
- Chumakova G.A., Kuznetsova T.Yu., Druzhilov M.A. Diversity of hypertension in obesity. Russian Journal of Cardiology. 2023;28(4):5360. doi: 10.15829/1560-4071-2023-5360 EDN: KJDGWY
- Khawaja AP, Springelkamp H, Creuzot-Garcher C, et al., The European Eye Epidemiology C. Associations with Intraocular Pressure Across Europe: The European Eye Epidemiology (E3) Consortium. Eur. J. Epidemiol. 2016;31(11):1101-1111. doi: 10.1007/s10654-016-0191-1 EDN: YWCLYL
- Cui Y, Yang X, Zhang G, et al. Intraocular Pressure in General and Diabetic Populations From Southern China: The Dongguan Eye Study. Invest. Ophthalmol. Visual Sci. 2019;60(2):761-769. doi: 10.1167/iovs.18-25247
- Hoehn R, Mirshahi A, Hoffmann EM, et al. Distribution of Intraocular Pressure and Its Association with Ocular Features and Cardiovascular Risk Factors: The Gutenberg Health Study. Ophthalmology. 2013;120(5):961-968. doi: 10.1016/j.ophtha.2012.10.031
- Qureshi IA. Intraocular pressure: a comparative analysis in two sexes. Clin. Physiol. 1997;17(3):247–255. doi: 10.1111/j.1365-2281.1997.tb00004.x
- Hashemi H, Khabazkhoob M, Emamian MH, et al. Distribution of Intraocular Pressure and Its Determinants in an Iranian Adult Population. Int. J. Ophthalmol. 2016;9(8):1207-1214. doi: 10.18240/ijo.2016.08.19
- Foster PJ, Machin D, Wong TY, et al. Determinants of Intraocular Pressure and Its Association with Glaucomatous Optic Neuropathy in Chinese Singaporeans: the Tanjong Pagar Study. Invest. Ophthalmol. Visual Sci. 2003;44(9):3885-91. doi: 10.1167/iovs.03-0012
- Rochtchina E, Mitchell P, Wang JJ. Relationship Between Age and Intraocular Pressure: the Blue Mountains Eye Study. Graefe's Arch. Clin. Exp. Ophthalmol. 2002;30(3):173-175. doi: 10.1046/j.1442-9071.2002.00519.x EDN: BADWVR
- Klein BE, Klein R. Intraocular Pressure and Cardiovascular Risk Variables. Arch. Ophthalmol. 1981;99(5):837-839. doi: 10.1001/archopht.1981.03930010837009
- Leske MC, Podgor MJ. Intraocular Pressure, Cardiovascular Risk Variables, and Visual Field Defects. Am. J. Epidemiol. 1983;118(2):280-287. doi: 10.1093/oxfordjournals.aje.a113634 EDN: IKJJYT
- Chumakova GA, Kuznecova TYu, Druzhilov MA., Veselovskaya NG. Obesity induced hypertension: The main pathophysiological mechanisms. Arterial'naya gipertenziya (Arterial Hypertension). 2021;27(3):260-268. doi: 10.18705/1607-419X-2021-27-3-260-268 EDN: OEYVXU
- Demidova TYu, Grickevich EYu. Obesity and Arterial Hypertension: Mechanisms and Possibilities of Therapy. FOCUS. Endokrinologiya. 2020;1(1):52-59. doi: 10.47407/ef2020.1.1.0007 EDN: LJFDXC
- Boyarinova MA., Rotar' OP, Konradi AO. Adipokines and Cardiometabolic Syndrome. Arterial'naya gipertenziya (Arterial Hypertension). 2014;20(5):422-432. doi: 10.18705/1607-419X2014-20-5-422-432 EDN: TAIGXD
- Wagner J, Danser AHJ, Derkx FH. et al. Demonstration of Renin mRNA, Angiotensinogen mRNA, and Angiotensin Converting Enzyme mRNA Expression in the Human Eye: Evidence for an Intraocular Renin-angiotensin System. Br. J. Ophthalmol. – 1996;80(2):159-163. doi: 10.1136/bjo.80.2.159
- Murata M, Nakagawa M, Takahashi S. Expression and Localisation of Angiotensin II Type 1 Receptor mRNA in Rat Ocular Tissues. Ophtalmologica. 1997;211(6):384-386. doi: 10.1159/000310835
- Shestakova MV. The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications. Saharnyj diabet (Diabetes mellitus). 2010;13(3):14-19. (In Russ.)doi: 10.14341/2072-0351-5481 EDN: NDKACL
- Likhvantseva VG, Korosteleva EV, Kovelenova IV, et al. Eye blood flow deficiency is the key factor determining the form of the secondary glaucoma in endocrine ophthalmopath. Russian Ophthalmological Journal. 2016;9(3):43-49. doi: 10.21516/2072-0076-2016-9-3-43-49
- Likhvantseva VG, Korosteleva EV, Tabeyeva KI, Vygodin VA. The Associative Link Between Thyroid Gland Diseases And Primary Open-Angle Glaucoma. Glaukoma. 2013;2:19-22. EDN: RSNOLV
- Cross JM, Girkin CA, Owsley C, McGwin G. The Association Between Thyroid Problems and Glaucoma. PLoS One. 2015;10(7): e0133688
- Lee AJ, Rochtchina E., Wang JJ, et al. Open-angle glaucoma and systemic thyroid disease in an older population: The Blue Mountains Eye Study. Eye (Lond). – 2004;18:600-608. doi: 10.1038/sj.eye.670073
- Kakigi C, Kasuga T, Wang Y, et al. Hypothyroidism and Glaucoma in The United States. PLoS One. 2015;10(7): e0133688. doi: 10.1371/journal.pone.0133688
- Karadimas P, Bouzas EA, Topouzis F, et al. Hypothyroidism and glaucoma. A study of 100 hypothyroid patients. Am. J. Ophthalmol. 2001;131:126-128. doi: 10.1016/s0002-9394(00)00724-8
- Motsko SP, Jones JK. Is There an Association between Hypothyroidism and Open-Angle Glaucoma in an Elderly Population? An Epidemiologic Study. Ophthalmology. 2008;115(9):1581-1584. doi: 10.1016/j.ophtha.2008.01.016
- Duncan KG, Jumper MD, Ribeiro RC, et al. Human Trabecular Meshwork Cells as a Thyroid Hormone Target Tissue: Presence of Functional Thyroid Hormone Receptors. Graefe's Arch/ Clin. Exp. Ophthalmol. 1999;237:231-240. doi: 10.1007/s004170050224
- Smith KD, Arthurs BP, Saheb N. An Association between Hypothyroidism and Primary Open-Angle Glaucoma. Ophthalmology. .1993;100(10):1580-1584. doi: 10.1016/S0161-6420(93)31441-7
- Beletskaya IS, Karonova TL, Astakhov S.Y. 25-Hydroxyvitamin D and matrix metalloproteinases-2, -9 level in patients with primary open angle glaucoma and pseudoexfoliative glaucoma/syndrome. Ophthalmology Reports. 2017;T(1):10-16. doi: 10.17816/OV10110-16 EDN: YNAGQF
- Yoo TK, Oh E, Hong S. Is Vitamin D Status Associated with Open-angle Glaucoma? A Cross-Sectional Study from South Korea. Public Health Nutr. 2014;17(4):833-843. doi: 10.1017/S1368980013003492
- Goncalves A, Milea D, Gohier P, et al. Serum Vitamin D Status Is Associated with the Presence But Not the Severity оf Primary Open Angle Glaucoma. Maturitas. 2015;81(4):470-474. doi: 10.1016/j.maturitas.2015.05.008
- Pigarova EA, Rozhinskaya L.Ya., Belaya J.E., et al. Russian Association of Endocrinologists Recommendations for Diagnosis, Treatment and Prevention of Vitamin D Deficiency in Adults. Problems of Endocrinology. 2016;62(4):60-84. doi: 10.14341/probl201662460-84 EDN: WMZICF
- Garcion E, Sindji L, Nataf S, et al. Treatment of Experimental AutoImmune Encephalomyelitis In Rat by 1,25-Dihydroxyvitamin D3 Leads to Early Effects Within the Central Nervous System. Acta Neuropathol. 2003;105:438-448. doi: 10.1007/s00401-002-0663-0 EDN: ESHQJN
- Kutuzova GD, Gabelt BT, Kiland JA, et al. 1α,25-Dihydroxyvitamin D3 and Its Analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD), Suppress Intraocular Pressure in Non-human Primates. Arch. Biochem. Biophys. 2012;518(1):53-60. doi: 10.1016/j.abb.2011.10.022
- Yin Z, Pintea V, Lin Y, et al. Vitamin D enhances corneal epithelial barrier function. Invest. Ophthalmol. Visual Sci. 2011;52(10):7359-7364. doi: 10.1167/iovs.11-7605
- Lin Y, Ubels JL, Schotanus MP, et al. Enhancement of Vitamin D Metabolites in the Eye Following Vitamin D3 Supplementation and UV-B Irradiation. Curr. Eye Res. 2012;37(10):871-878. doi: 10.3109/02713683.2012.688235
- Alsalem JA, Patel D, Susarla R, et al. Characterization of Vitamin D Production by Human Ocular Barrier Cells. Invest. Ophthalmol. Visual Sci. 2014;55(4):2140-2147. doi: 10.1167/iovs.13-13019
- Zhivotovsky B, Orrenius S. Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium. 2011;50(3):211-221. doi: 10.1016/j.ceca.2011.03.003 EDN: PDZTPH
- Beletskaya IS, Astakhov SY, Karonova TL, et al. Pseudoexfoliative glaucoma and molecular genetic characteristics of vitamin D metabolism. Ophthalmology Reports. 2018;11(2):19-28. doi: 10.17816/OV11219-28 EDN: XQCJWP
补充文件




